Molecule Information

General Information of the Molecule (ID: Mol01295)

Name	Long non-protein coding RNA 958 (LINC00958) ,Homo sapiens
Synonyms	LINC00958 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	LINC00079, MIR1204HG, NCRNA00079, onco-lncRNA-100
Gene ID	100506305
Location	chr11:12961541-12989597[-]
Ensembl ID	ENSG00000251381
HGNC ID	HGNC:48671
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Fluorouracil

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Colorectal cancer				[1]
Resistant Disease	Colorectal cancer [ICD-11: 2B91.1]			Disease Info
Resistant Drug	Fluorouracil			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell invasion		Activation	hsa05200
	Cell migration		Activation	hsa04670
	Cell proliferation		Activation	hsa05200
In Vitro Model	DLD1 cells	Colon	Homo sapiens (Human)	CVCL_0248
	SW620 cells	Colon	Homo sapiens (Human)	CVCL_0547
Experiment for Molecule Alteration	RT-qPCR
Experiment for Drug Resistance	MTT assay; Colony formation assay
Mechanism Description	BLACAT2 contributes to the cell proliferation, its levels were significantly increased in 5-fluorouracil-resistant cells, and overexpression of BLACAT2 was markedly associated with a low cell inhibition rate.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Colorectal cancer [ICD-11: 2B91]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Rectum
The Specified Disease	Rectum adenocarcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.23E-01; Fold-change: -4.68E-01
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
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Tissue-specific Molecule Abundances in Healthy Individuals

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Download the Tissue-Specific Variation(s) Profile

References

Ref 1	Long non-coding RNA bladder cancer-associated transcript 2 contributes to disease progression, chemoresistance and poor survival of patients with colorectal cancer. Oncol Lett. 2019 Aug;18(2):2050-2058. doi: 10.3892/ol.2019.10487. Epub 2019 Jun 18.