Molecule Information

General Information of the Molecule (ID: Mol01258)

Name	Small nucleolar RNA host gene 15 (SNHG15) ,Homo sapiens
Synonyms	SNHG15 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	AC078883.3
Gene ID	285958
Location	chr7:44983019-44986961[-]
Ensembl ID	ENSG00000232956
HGNC ID	HGNC:27797
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Fluorouracil

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Colorectal cancer				[1]
Resistant Disease	Colorectal cancer [ICD-11: 2B91.1]			Disease Info
Resistant Drug	Fluorouracil			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	Cell invasion		Activation	hsa05200
	Cell migration		Activation	hsa04670
	Cell proliferation		Activation	hsa05200
In Vitro Model	HCT116 cells	Colon	Homo sapiens (Human)	CVCL_0291
	LOVO cells	Colon	Homo sapiens (Human)	CVCL_0399
In Vivo Model	BALB/c-Rag2/-IL2cc/immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	Flow cytometry assay; Colony formation assay; MTS kit assay
Mechanism Description	The levels of SNHG15 are related with the capacity of CRC cells to cope with the cytotoxic stress caused by 5-FU, which could be mediated by its interaction with AIF.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Colorectal cancer [ICD-11: 2B91]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Rectum
The Specified Disease	Rectum adenocarcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.91E-10; Fold-change: -1.47E-01
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
Download Molecule expression barchart for all samples Download Molecule expression data of patients in the disease section of the tissue Download Molecule expression data in the tissue of healthy individual

Tissue-specific Molecule Abundances in Healthy Individuals

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Download the Tissue-Specific Variation(s) Profile

References

Ref 1	SNHG15 is a bifunctional MYC-regulated noncoding locus encoding a lncRNA that promotes cell proliferation, invasion and drug resistance in colorectal cancer by interacting with AIF. J Exp Clin Cancer Res. 2019 Apr 24;38(1):172. doi: 10.1186/s13046-019-1169-0.