Molecule Information

General Information of the Molecule (ID: Mol01246)

Name	PCGEM1 prostate-specific transcript (PCGEM1) ,Homo sapiens
Synonyms	PCGEM1 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	onco-lncRNA-12
Gene ID	64002
Location	chr2:192749845-192776899[+]
Ensembl ID	ENSG00000227418
HGNC ID	HGNC:30145
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Doxorubicin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Prostate cancer				[1]
Resistant Disease	Prostate cancer [ICD-11: 2C82.0]			Disease Info
Resistant Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	LNCaP cells	Prostate	Homo sapiens (Human)	CVCL_0395
Experiment for Molecule Alteration	Northern blotting analysis
Experiment for Drug Resistance	Flow cytometry assay
Mechanism Description	PCGEM1overexpression in LNCaP cell culturemodel results in the inhibition of apoptosis induced by doxorubicin (DOX). Induction of p53 and p21Waf1/Cip1by DOX were delayed in LNCaP cells stably overexpressing PCGEM1(LNCaP-PCGEM1cells) compared tocontrol LNCaP cells.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Prostate cancer [ICD-11: 2C82]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Prostate
The Specified Disease	Prostate adenocarcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.59E-09; Fold-change: -2.19E-01
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
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Tissue-specific Molecule Abundances in Healthy Individuals

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Download the Tissue-Specific Variation(s) Profile

References

Ref 1	Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1. DNA Cell Biol. 2006 Mar;25(3):135-41. doi: 10.1089/dna.2006.25.135.