Molecule Information

General Information of the Molecule (ID: Mol01217)

• Name: MIR31 host gene (MIR31HG) ,Homo sapiens
• Synonyms: MIR31HG
• Molecule Type: LncRNA
• Gene Name: P2Y1, SARCC
• Gene ID: 554202
• Location: chr9:21453802-21559900[-]
• Ensembl ID: ENSG00000171889
• HGNC ID: HGNC:37187

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Gefitinib

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Non-small cell lung cancer [1]

• Resistant Disease: Non-small cell lung cancer [ICD-11: 2C25.Y]
• Resistant Drug: Gefitinib
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: EGFR/PI3K/AKT signaling pathway; Regulation; hsa01521
• In Vitro Model: PC9 cells; Lung; Homo sapiens (Human); CVCL_B260
• In Vitro Model: PC9R cells; Lung; Homo sapiens (Human); CVCL_D778
• Experiment for Molecule Alteration: RT-qPCR
• Experiment for Drug Resistance: CCK8 assay; Annexin V-FITC/PI double staining assay
• Mechanism Description: Increased MIR31HG LncRNA expression increases gefitinib resistance in non-small cell lung cancer cell lines through the EGFR/PI3k/AkT signaling pathway.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

Lung cancer [ICD-11: 2C25]

Differential expression of molecule in resistant diseases

• The Studied Tissue: Lung
• The Specified Disease: Lung adenocarcinoma
• The Expression Level of Disease Section Compare with the Healthy Individual Tissue: p-value: 3.37E-11; Fold-change: -6.18E-01
• The Studied Tissue: Lung
• The Specified Disease: Lung squamous cell carcinoma
• The Expression Level of Disease Section Compare with the Healthy Individual Tissue: p-value: 3.54E-16; Fold-change: -7.67E-01

References

• Ref 1: Increased MIR31HG lncRNA expression increases gefitinib resistance in non-small cell lung cancer cell lines through the EGFR/PI3K/AKT signaling pathway. Oncol Lett. 2017 May;13(5):3494-3500. doi: 10.3892/ol.2017.5878. Epub 2017 Mar 20.