Molecule Information

General Information of the Molecule (ID: Mol01179)

Name	H3 lysine 27 trimethylation (H3K27) ,Homo sapiens
Molecule Type	Protein
Gene Name	H3K27
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s)

3 drug(s) in total

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Cisplatin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Disease Class: Lung small cell carcinoma [ICD-11: 2C25.2]				[1]
Resistant Disease	Lung small cell carcinoma [ICD-11: 2C25.2]			Disease Info
Resistant Drug	Cisplatin			Drug Info
Molecule Alteration	Methylation		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
In Vitro Model	NCI-H446 cells	Lung	Homo sapiens (Human)	CVCL_1562
	NCI-H69 cells	Lung	Homo sapiens (Human)	CVCL_1579
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CCK8 assay; Flow cytometry assay
Mechanism Description	H3kH3k27me3 induces multidrug resistance in small cell lung cancer by affecting HOXA1 DNA methylation via regulation of the LncRNA HOTAIR.

Doxorubicin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Disease Class: Lung small cell carcinoma [ICD-11: 2C25.2]				[1]
Resistant Disease	Lung small cell carcinoma [ICD-11: 2C25.2]			Disease Info
Resistant Drug	Doxorubicin			Drug Info
Molecule Alteration	Methylation		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
In Vitro Model	NCI-H446 cells	Lung	Homo sapiens (Human)	CVCL_1562
	NCI-H69 cells	Lung	Homo sapiens (Human)	CVCL_1579
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CCK8 assay; Flow cytometry assay
Mechanism Description	H3kH3k27me3 induces multidrug resistance in small cell lung cancer by affecting HOXA1 DNA methylation via regulation of the LncRNA HOTAIR.

Etoposide

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Disease Class: Lung small cell carcinoma [ICD-11: 2C25.2]				[1]
Resistant Disease	Lung small cell carcinoma [ICD-11: 2C25.2]			Disease Info
Resistant Drug	Etoposide			Drug Info
Molecule Alteration	Methylation		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
In Vitro Model	NCI-H446 cells	Lung	Homo sapiens (Human)	CVCL_1562
	NCI-H69 cells	Lung	Homo sapiens (Human)	CVCL_1579
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CCK8 assay; Flow cytometry assay
Mechanism Description	H3kH3k27me3 induces multidrug resistance in small cell lung cancer by affecting HOXA1 DNA methylation via regulation of the LncRNA HOTAIR.

References

Ref 1	H3K27me3 induces multidrug resistance in small cell lung cancer by affecting HOXA1 DNA methylation via regulation of the lncRNA HOTAIR. Ann Transl Med. 2018 Nov;6(22):440. doi: 10.21037/atm.2018.10.21.