Molecule Information

General Information of the Molecule (ID: Mol00982)

• Name: Kasugamycin 2' acetyltransferase (KA2A) ,Paenibacillus sp.
• Synonyms: aac(2')-IIb; AK95_15585; 2')-IIb
• Molecule Type: Protein
• Gene Name: aac(2')-IIb
• Sequence:
  MNHRKGNEPTAAALMELHVLAMFTHDGNMQIRTINEPWPGEELAPRFFMGRTIDGSSICR
  FRHDVPEGIAGQLRALVEDEPIVTEEVLTRPKHFAAYMNLLRAEHYTSGPCYRIPDQTTQ
  AKQTVRITPGNIREYSLTGFEWLTTEIDYDQPCVALIHENRVVSVCRSVRITERAHEAGL
  ETSEEFRGRGYAAAVVAGWAIEVQKMGALALYSTLWGNSSSRRVANKLGLSYYGVNFTIS
• Uniprot ID: A0A1I9ZKL2_9BACL

Kingdom: N.A.
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Paenibacillaceae
Genus: Paenibacillus
Species: Paenibacillus sp.

Type(s) of Resistant Mechanism of This Molecule

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Kasugamycin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Bacterial infection [1]

• Resistant Disease: Bacterial infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Kasugamycin
• Molecule Alteration: Expression; Inherence
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Paenibacillus sp. LC231; 1120679
• Experiment for Molecule Alteration: Whole genome sequence assay
• Experiment for Drug Resistance: Broth microdilution method assay
• Mechanism Description: Aminoglycoside acetyltransferases can often modify a variety of aminoglycosides and we therefore evaluated the ability of AAC(2')-IIb to modify a range of aminoglycosides. AAC(2')-IIb specifically modified kasugamycin and no other aminoglycoside by acetylation.

References

• Ref 1: A diverse intrinsic antibiotic resistome from a cave bacterium. Nat Commun. 2016 Dec 8;7:13803. doi: 10.1038/ncomms13803.