Molecule Information

General Information of the Molecule (ID: Mol00558)

Name	Phosphoglycerate kinase 1 (PGK1) ,Homo sapiens
Synonyms	Cell migration-inducing gene 10 protein; Primer recognition protein 2; PRP 2; PGKA; MIG10; OK/SW-cl.110 Click to Show/Hide
Molecule Type	Protein
Gene Name	PGK1
Gene ID	5230
Location	chrX:77910739-78129295[+]
Sequence	MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVL MSHLGRPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLE NLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVN LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGM AFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQ ATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVV KATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSNI Click to Show/Hide
Function	Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. Click to Show/Hide
Uniprot ID	PGK1_HUMAN
Ensembl ID	ENSG00000102144
HGNC ID	HGNC:8896
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Doxorubicin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Disease Class: Gallbladder cancer				[1]
Resistant Disease	Gallbladder cancer [ICD-11: 2C13.0]			Disease Info
Resistant Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell autophagy		Activation	hsa04140
	GBCD/Rlnc1/PGK1 signaling pathway		Activation	hsa04066
In Vitro Model	GBC-SD cells	Gallbladder	Homo sapiens (Human)	CVCL_6903
	NOZ cells	Gallbladder	Homo sapiens (Human)	CVCL_3079
In Vivo Model	Nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	RNA immunoprecipitation; Western blot analysis
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	LncRNA GBCDRlnc1 induces autophagy and drug-resistance of gallbladder cancer cells by interacting with PGk1 and preventing its degradation, which eventually upregulates ATG5-ATG12 expression.

References

Ref 1	Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy. Mol Cancer. 2019 Apr 5;18(1):82. doi: 10.1186/s12943-019-1016-0.