Drug Information
Drug (ID: DG01859) and It's Reported Resistant Information
| Name |
Spliceosome inhibitors
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| Synonyms |
Spliceosome inhibitors
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| Target | . | NOUNIPROTAC | [1] | ||
Type(s) of Resistant Mechanism of This Drug
ADTT: Aberration of the Drug's Therapeutic Target
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
Solid tumour/cancer [ICD-11: 2A00-2F9Z]
| Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | ||||
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Aberration of the Drug's Therapeutic Target (ADTT)
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| Key Molecule: Splicing factor 3B subunit 1 (SF3B1) | [1] | |||
| Molecule Alteration | Missense mutation | p.K700E (c.2098A>G) |
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| Sensitive Disease | Solid tumour/cancer [ICD-11: 2A00-2F9Z] | |||
| Experimental Note | Revealed Based on the Cell Line Data | |||
| In Vitro Model | PANC-1 cells | Pancreas | Homo sapiens (Human) | CVCL_0480 |
| Capan-1 cells | Pancreas | Homo sapiens (Human) | CVCL_0237 | |
| Capan-2 cells | Pancreas | Homo sapiens (Human) | CVCL_0026 | |
| HEC1A cells | Uterus | Homo sapiens (Human) | CVCL_0293 | |
| Panc 0504 cells | Pancreas | Homo sapiens (Human) | CVCL_1637 | |
| MFE296 cells | Endometrium | Homo sapiens (Human) | CVCL_1406 | |
| HEC59 cells | Endometrium | Homo sapiens (Human) | CVCL_2930 | |
| ESS-1 cells | Endometrium | Homo sapiens (Human) | CVCL_1205 | |
| Experiment for Drug Resistance |
CellTiter-Glo assay; IC50 assay | |||
| Key Molecule: Splicing factor 3B subunit 1 (SF3B1) | [1] | |||
| Molecule Alteration | Missense mutation | p.K666N (c.1998G>C) |
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| Sensitive Disease | Solid tumour/cancer [ICD-11: 2A00-2F9Z] | |||
| Experimental Note | Revealed Based on the Cell Line Data | |||
| In Vitro Model | PANC-1 cells | Pancreas | Homo sapiens (Human) | CVCL_0480 |
| Capan-1 cells | Pancreas | Homo sapiens (Human) | CVCL_0237 | |
| Capan-2 cells | Pancreas | Homo sapiens (Human) | CVCL_0026 | |
| HEC1A cells | Uterus | Homo sapiens (Human) | CVCL_0293 | |
| Panc 0504 cells | Pancreas | Homo sapiens (Human) | CVCL_1637 | |
| MFE296 cells | Endometrium | Homo sapiens (Human) | CVCL_1406 | |
| HEC59 cells | Endometrium | Homo sapiens (Human) | CVCL_2930 | |
| ESS-1 cells | Endometrium | Homo sapiens (Human) | CVCL_1205 | |
| Experiment for Drug Resistance |
CellTiter-Glo assay; IC50 assay | |||
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