Drug Information

Drug (ID: DG01857) and It's Reported Resistant Information

• Name: SU5402
• Synonyms: SU5402
• Indication:
  In total 1 Indication(s)
  Multiple myeloma [ICD-11: 2A83]; Phase 1; [1]
• Target: Fibroblast growth factor receptor 3 (FGFR3); FGFR3_HUMAN; [1]

Type(s) of Resistant Mechanism of This Drug

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Myeloproliferative neoplasm [ICD-11: 2A22]

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Key Molecule: Fibroblast growth factor receptor 3 (FGFR3) [1]

• Molecule Alteration: Missense mutation; p.K650E (c.1948A>G)
• Sensitive Disease: Myeloproliferative neoplasm [ICD-11: 2A22.0]
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: Blood vessel; N.A.
• Experiment for Molecule Alteration: Mass spectrum assay
• Experiment for Drug Resistance: CellTiter 96 aqueous one solution cell proliferation assay
• Mechanism Description: The missense mutation p.K650E (c.1948A>G) in gene FGFR3 cause the sensitivity of SU5402 by aberration of the drug's therapeutic target

References

• Ref 1: Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric propertiesCancer Cell. 2013 Apr 15;23(4):477-88. doi: 10.1016/j.ccr.2013.02.019.