Drug Information

Drug (ID: DG01853) and It's Reported Resistant Information

• Name: Induction therapy
• Synonyms: Induction therapy
• Target: .; NOUNIPROTAC; [1]

Type(s) of Resistant Mechanism of This Drug

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Acute myeloid leukemia [ICD-11: 2A60]

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: Nucleophosmin (NPM1) [1]

• Molecule Alteration: FS-deletion; p.W288fs (c.863_864)
• Sensitive Disease: Acute myeloid leukemia [ICD-11: 2A60.0]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Bone marrow; N.A.
• Experiment for Molecule Alteration: Immunostaining assay
• Mechanism Description: The fs-deletion p.W288fs (c.863_864) in gene NPM1 cause the sensitivity of Induction Therapy by unusual activation of pro-survival pathway.

References

• Ref 1: Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotypeN Engl J Med. 2005 Jan 20;352(3):254-66. doi: 10.1056/NEJMoa041974.