Drug Information

Drug (ID: DG01808) and It's Reported Resistant Information

• Name: Heliox
• Synonyms: Heliox; helium;molecular oxygen; 58933-55-4; Helium, mixed with oxygen; Helium-oxygen mixture; Helium:oxygen mixture; Compressed gas, N.O.S.; Oxygen mixture with helium; Oxygen, mixed with helium; Heliox gas; Helium oxygen gas; Heliox, hyperbaric; Helium, mixt. with oxygen; Compressed gas, N.O.S. (helium, oxygen) gas; 70356-00-2
• Drug Resistance Disease(s):
  Disease(s) with Resistance Information Discovered by Cell Line Test for This Drug (1 diseases)
  Ischemic cardiovascular disease [ICD-11: BA51]; [1]
• Target: .; NOUNIPROTAC; [1]
• IsoSMILES: [He].O=O
• InChI: InChI=1S/He.O2/c;1-2
• InChIKey: GWUAFYNDGVNXRS-UHFFFAOYSA-N
• PubChem CID: 123812

Type(s) of Resistant Mechanism of This Drug

  RTDM: Regulation by the Disease Microenvironment

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-11: Circulatory system diseases

Ischemic cardiovascular disease [ICD-11: BA51]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Regulation by the Disease Microenvironment (RTDM)

Key Molecule: Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) [1]

• Molecule Alteration: Up-regulation; Interaction
• Resistant Disease: Ischemic cardiovascular disease [ICD-11: BA51.0]
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: HCAECs; N.A.; .; N.A.
• In Vivo Model: Hind limb ischemia rat model; Rattus norvegicus
• Experiment for Molecule Alteration: Overexpression assay; Knockdown assay; Luciferase assay
• Experiment for Drug Resistance: CellTiter-Glo assay; dual-luciferase reporter assay
• Mechanism Description: Hyperbaric oxygen boosts long noncoding RNA MALAT1 exosome secretion to suppress microRNA-92a expression in therapeutic angiogenesis.

References

• Ref 1: Long non-coding RNA MALAT1 interacts with transcription factor Foxo1 to regulate SIRT1 transcription in high glucose-induced HK-2 cells injuryBiochem Biophys Res Commun. 2018 Sep 5;503(2):849-855. doi: 10.1016/j.bbrc.2018.06.086. Epub 2018 Jul 14.