Drug Information

Drug (ID: DG01808) and It's Reported Resistant Information

Name	Heliox
Synonyms	Heliox; helium;molecular oxygen; 58933-55-4; Helium, mixed with oxygen; Helium-oxygen mixture; Helium:oxygen mixture; Compressed gas, N.O.S.; Oxygen mixture with helium; Oxygen, mixed with helium; Heliox gas; Helium oxygen gas; Heliox, hyperbaric; Helium, mixt. with oxygen; Compressed gas, N.O.S. (helium, oxygen) gas; 70356-00-2 Click to Show/Hide
Structure
Drug Resistance Disease(s)	Disease(s) with Resistance Information Discovered by Cell Line Test for This Drug (1 diseases) Ischemic cardiovascular disease [ICD-11: BA51] [1]
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IsoSMILES	[He].O=O
InChI	InChI=1S/He.O2/c;1-2
InChIKey	GWUAFYNDGVNXRS-UHFFFAOYSA-N
PubChem CID	123812

Type(s) of Resistant Mechanism of This Drug

RTDM: Regulation by the Disease Microenvironment

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-11: Circulatory system diseases

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Ischemic cardiovascular disease [ICD-11: BA51]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Regulation by the Disease Microenvironment (RTDM)			Click to Show/Hide
Key Molecule: Metastasis associated lung adenocarcinoma transcript 1 (MALAT1)				[1]
Resistant Disease	Ischemic cardiovascular disease [ICD-11: BA51.0]			Disease Info
Molecule Alteration	Up-regulation		Interaction	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HCAECs	N.A.	N.A.	N.A.
In Vivo Model	Hind limb ischemia rat model			Rattus norvegicus
Experiment for Molecule Alteration	Overexpression assay; Knockdown assay; Luciferase assay
Experiment for Drug Resistance	CellTiter-Glo assay; dual-luciferase reporter assay
Mechanism Description	Hyperbaric oxygen boosts long noncoding RNA MALAT1 exosome secretion to suppress microRNA-92a expression in therapeutic angiogenesis.

References

Ref 1	Long non-coding RNA MALAT1 interacts with transcription factor Foxo1 to regulate SIRT1 transcription in high glucose-induced HK-2 cells injuryBiochem Biophys Res Commun. 2018 Sep 5;503(2):849-855. doi: 10.1016/j.bbrc.2018.06.086. Epub 2018 Jul 14.