Disease Information

General Information of the Disease (ID: DIS00398)

• Name: Ischemic cardiovascular disease
• ICD: ICD-11: BA51

Type(s) of Resistant Mechanism of This Disease

  RTDM: Regulation by the Disease Microenvironment

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Heliox

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Regulation by the Disease Microenvironment (RTDM)

Key Molecule: Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) [1]

• Resistant Disease: Ischemic cardiovascular disease [ICD-11: BA51.0]
• Resistant Drug: Heliox
• Molecule Alteration: Up-regulation; Interaction
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: HCAECs; N.A.; N.A.; N.A.
• In Vivo Model: Hind limb ischemia rat model; Rattus norvegicus
• Experiment for Molecule Alteration: Overexpression assay; Knockdown assay; Luciferase assay
• Experiment for Drug Resistance: CellTiter-Glo assay; dual-luciferase reporter assay
• Mechanism Description: Hyperbaric oxygen boosts long noncoding RNA MALAT1 exosome secretion to suppress microRNA-92a expression in therapeutic angiogenesis.

References

• Ref 1: Long non-coding RNA MALAT1 interacts with transcription factor Foxo1 to regulate SIRT1 transcription in high glucose-induced HK-2 cells injuryBiochem Biophys Res Commun. 2018 Sep 5;503(2):849-855. doi: 10.1016/j.bbrc.2018.06.086. Epub 2018 Jul 14.