Drug Information

Drug (ID: DG01559) and It's Reported Resistant Information

• Name: ER2
• Synonyms: ER2
• Target: .; NOUNIPROTAC; [1]
• IsoSMILES: [SH-].[SH-].[SH-].[SH-].[Fe].[Fe].[Fe].[Fe]
• InChI: InChI=1S/4Fe.4H2S/h;;;;4*1H2/p-4
• InChIKey: PTTXNOSMDBWCQD-UHFFFAOYSA-J
• PubChem CID: 42626654

Type(s) of Resistant Mechanism of This Drug

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Lung cancer [ICD-11: 2C25]

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: Epidermal growth factor receptor (EGFR) [1]

• Molecule Alteration: IF-deletion; p.E746_A750delELREA (c.2236_2250del15)
• Sensitive Disease: Lung adenocarcinoma [ICD-11: 2C25.0]
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: EGFR signaling pathway; Inhibition; hsa01521
• In Vitro Model: H1975 cells; Lung; Homo sapiens (Human); CVCL_1511
• In Vitro Model: A549 cells; Lung; Homo sapiens (Human); CVCL_0023
• In Vitro Model: H460 cells; Lung; Homo sapiens (Human); CVCL_0459
• In Vitro Model: H1299 cells; Lung; Homo sapiens (Human); CVCL_0060
• In Vitro Model: HCC827 cells; Lung; Homo sapiens (Human); CVCL_2063
• In Vitro Model: PC9 cells; Lung; Homo sapiens (Human); CVCL_B260
• In Vitro Model: PC9GR cells; Lung; Homo sapiens (Human); CVCL_V337
• In Vitro Model: H358 cells; Lung; Homo sapiens (Human); CVCL_1559
• In Vitro Model: H322 cells; Lung; Homo sapiens (Human); CVCL_1556
• In Vivo Model: Female athymic BALB-c/nu mouse PDX model; Mus musculus
• Experiment for Molecule Alteration: Western blotting analysis
• Experiment for Drug Resistance: FACS assay; Propidium iodide staining assay
• Mechanism Description: ER2 suppressed EGFR pathway and induced G1 arrest and apoptosis in NSCLC cells. ER2 inhibited EGF-stimulated VEGF production. ER2 induced anti-tumor activity in combination with cisplatin in xenograft models.

References

• Ref 1: ER2, a novel human anti-EGFR monoclonal antibody inhibit tumor activity in non-small cell lung cancer modelsLung Cancer. 2016 May;95:57-64. doi: 10.1016/j.lungcan.2016.02.013. Epub 2016 Feb 27.