Drug Information

Drug (ID: DG00504) and It's Reported Resistant Information

• Name: Tunicamycin
• Drug Resistance Disease(s):
  Disease(s) with Resistance Information Validated by in-vivo Model for This Drug (1 diseases)
  Sepsis [ICD-11: 1G40]; [1]
• DrugBank ID: DB13172

Type(s) of Resistant Mechanism of This Drug

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-01: Infectious/parasitic diseases

Sepsis [ICD-11: 1G40]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Key Molecule: Tunicamycin resistance protein (TMRB) [1]

• Molecule Alteration: Expression; Inherence
• Resistant Disease: Bacillus subtilis infection [ICD-11: 1G40.1]
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Bacillus subtilis strain; 1423
• In Vitro Model: Escherichia coli strain; 562
• Experiment for Molecule Alteration: SDS-PAGE assay
• Mechanism Description: Overproduction of TmrB protein, a 22.5-kDa protein with an N-terminal ATP-binding region and a C-terminal amphiphilic alpha-helix, confers resistance to tunicamycin on Bacillus subtilis. TmrB protein was found to bind Sepharose 6B to which tunicamycin was covalently linked. Experiments with mutant proteins found that the C-terminal region of TmrB protein might be involved in the binding to tunicamycin.

References

• Ref 1: TmrB protein, which confers resistance to tunicamycin on Bacillus subtilis, binds tunicamycin. Biosci Biotechnol Biochem. 1995 Feb;59(2):321-2. doi: 10.1271/bbb.59.321.