Drug Information

Drug (ID: DG00457) and It's Reported Resistant Information

• Name: Arylomycin C16
• Synonyms: Arylomycin C16; CHEMBL1784531; SCHEMBL14234622; BDBM50441139
• Drug Resistance Disease(s):
  Disease(s) with Clinically Reported Resistance for This Drug (1 diseases)
  Pneumonia [ICD-11: CA40]; [1], [2]
• Formula: C46H68N6O11
• IsoSMILES: CCCCCCCCCCCCCCCC(=O)N(C)[C@H](CO)C(=O)N[C@H](C)C(=O)NCC(=O)N(C)[C@H]1C2=CC(=C(C=C2)O)C3=C(C=CC(=C3)C[C@H](NC(=O)[C@@H](NC1=O)C)C(=O)O)O
• InChI: 1S/C46H68N6O11/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-39(56)51(4)36(28-53)44(60)48-29(2)42(58)47-27-40(57)52(5)41-32-21-23-38(55)34(26-32)33-24-31(20-22-37(33)54)25-35(46(62)63)50-43(59)30(3)49-45(41)61/h20-24,26,29-30,35-36,41,53-55H,6-19,25,27-28H2,1-5H3,(H,47,58)(H,48,60)(H,49,61)(H,50,59)(H,62,63)/t29-,30+,35+,36-,41+/m1/s1
• InChIKey: HGWCKYGOWQEYSJ-JBWZRHCTSA-N
• PubChem CID: 54586211

Type(s) of Resistant Mechanism of This Drug

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-12: Respiratory system diseases

Pneumonia [ICD-11: CA40]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Key Molecule: Signal peptidase I (LEPB) [1], [2]

• Molecule Alteration: Missense mutation; p.S29P
• Resistant Disease: Streptococcus pneumoniae infection [ICD-11: AA80.2]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Staphylococcus capitis isolates strain; 29388
• In Vitro Model: Staphylococcus caprae isolates strain; 29380
• In Vitro Model: Staphylococcus cohnii isolates strain; 29382
• In Vitro Model: Staphylococcus epidermidis isolates strain; 1282
• In Vitro Model: Staphylococcus haemolyticus isolates strain; 1283
• In Vitro Model: Staphylococcus hominis isolates strain; 1290
• In Vitro Model: Staphylococcus lugdunensis isolates strain; 28035
• Experiment for Molecule Alteration: Genome sequence assay
• Experiment for Drug Resistance: Agar dilution method assay
• Mechanism Description: S. epidermidis evolves resistance to the arylomycins by mutating residue 29 of one of its two SPases, SpsIB, from Ser (Ser29) to Pro (Pro29).

References

• Ref 1: Positive selection in penicillin-binding proteins 1a, 2b, and 2x from Streptococcus pneumoniae and its correlation with amoxicillin resistance development. Infect Genet Evol. 2008 May;8(3):331-9. doi: 10.1016/j.meegid.2008.02.001. Epub 2008 Feb 14.
• Ref 2: In vitro activities of arylomycin natural-product antibiotics against Staphylococcus epidermidis and other coagulase-negative staphylococci. Antimicrob Agents Chemother. 2011 Mar;55(3):1130-4. doi: 10.1128/AAC.01459-10. Epub 2010 Dec 28.