Drug Information

Drug (ID: DG00399) and It's Reported Resistant Information

Name	4',6-Diamidino-2-phenylindole
Synonyms	DAPI; 4',6-Diamidino-2-phenylindole; 47165-04-8; 2-(4-carbamimidoylphenyl)-1H-indole-6-carboximidamide; 4',6-Diamidinophenyl-indole; CHEBI:51231; 2-(4-(Aminoiminomethyl)phenyl)-1H-indole-6-carboximidamide; UNII-K9W25Z7ROH; K9W25Z7ROH; 6-AMIDINE-2-(4-AMIDINO-PHENYL)INDOLE; 2-(4-carbamimidoylphenyl)-1H-indole-6-carboxamidine; DATI; 4',6-Diamino-2-phenylindol; CCRIS 3826; antifade; BRN 3557399; Indole-6-carboximidamide, 2-(4-(aminoiminomethyl)phenyl)-; MolMap_000017; CHEMBL48217; SCHEMBL235865; GTPL5498; NPE759; ZINC56538; DTXSID50963757; BDBM50010058; AKOS025213592; SMP1_000093; A827164; Q238382 Click to Show/Hide
Structure
Drug Resistance Disease(s)	Disease(s) with Clinically Reported Resistance for This Drug (1 diseases) Pneumonia [ICD-11: CA40] [1]
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Formula	C16H15N5
IsoSMILES	C1=CC(=CC=C1C2=CC3=C(N2)C=C(C=C3)C(=N)N)C(=N)N
InChI	1S/C16H15N5/c17-15(18)10-3-1-9(2-4-10)13-7-11-5-6-12(16(19)20)8-14(11)21-13/h1-8,21H,(H3,17,18)(H3,19,20)
InChIKey	FWBHETKCLVMNFS-UHFFFAOYSA-N
PubChem CID	2954

Type(s) of Resistant Mechanism of This Drug

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-12: Respiratory system diseases

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Pneumonia [ICD-11: CA40]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: MATE family efflux transporter (ABEM)			[1]
Resistant Disease	Acinetobacter baumannii infection [ICD-11: CA40.4]		Disease Info
Molecule Alteration	Expression	Inherence	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli kAM32		562
Experiment for Drug Resistance	MIC assay
Mechanism Description	AbeM was found to be an H+-coupled multidrug efflux pump and a unique member of the MATE family which lead to drug resistance.

References

Ref 1	AbeM, an H+-coupled Acinetobacter baumannii multidrug efflux pump belonging to the MATE family of transporters. Antimicrob Agents Chemother. 2005 Oct;49(10):4362-4. doi: 10.1128/AAC.49.10.4362-4364.2005.