Drug Information

Drug (ID: DG00352) and It's Reported Resistant Information

• Name: 2-Bromo-4-fluorobenzaldehyde
• Synonyms: 2-Bromo-4-fluorobenzaldehyde; 59142-68-6; 2-bromo-4-fluoro-benzaldehyde; 2-Bromo-4-Fluoro Benzaldehyde; Benzaldehyde, 2-bromo-4-fluoro-; MFCD00672923; 4-FLUORO-2-BROMOBENZALDEHYDE; Bromo-4-fluoro benzaldehyde; 2-Bromo-4-fluorobezaldehyde; 2-bromo4-fluoro-benzaldehyde; SCHEMBL249018; DTXSID70378369; ACT00250; BCP29430; ZINC2567808; BBL021382; STK894095; AKOS005144223; AB06851; AC-2291; AS03017; CM11837; CS-W007439; LS10393; MCULE-8213351363; PS-8173; VZ23974; 2-Bromo-4-fluorobenzaldehyde, AldrichCPR; BC002351; L203; SY014169; AB0014585; DB-024154; AM20060032; B3498; FT-0640583; 142B686; J-508293; 2-Bromo-4-Fluoro Benzaldehyde;Benzaldehyde, 2-bromo-4-fluoro-
• Formula: C7H4BrFO
• IsoSMILES: C1=CC(=C(C=C1F)Br)C=O
• InChI: 1S/C7H4BrFO/c8-7-3-6(9)2-1-5(7)4-10/h1-4H
• InChIKey: OPZDXMCOWFPQPE-UHFFFAOYSA-N
• PubChem CID: 2773319

Type(s) of Resistant Mechanism of This Drug

  EADR: Epigenetic Alteration of DNA, RNA or Protein

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Esophageal cancer [ICD-11: 2B70]

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: hsa-miR-127-3p [1]

• Sensitive Disease: Esophageal cancer [ICD-11: 2B70.1]
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: TE-1 cells; Esophagus; Homo sapiens (Human); CVCL_1759
• In Vitro Model: 293T cells; Breast; Homo sapiens (Human); CVCL_0063
• In Vitro Model: EC9706 cells; Esophagus; Homo sapiens (Human); CVCL_E307
• In Vitro Model: KYSE150 cells; Esophagus; Homo sapiens (Human); CVCL_1348
• In Vitro Model: EC109 cells; Esophagus; Homo sapiens (Human); CVCL_6898
• In Vitro Model: EC1 cells; Esophagus; Homo sapiens (Human); CVCL_DC74
• In Vitro Model: HEEC cells; Esophagus; Homo sapiens (Human); N.A.
• In Vivo Model: Nude mouse xenograft model; Mus musculus
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: MTT assay
• Mechanism Description: miroRNA-127-3p targets XRCC3 to enhance the chemosensitivity of esophageal cancer cells to a novel phenanthroline-dione derivative.

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: DNA repair protein XRCC3 (XRCC3) [1]

• Sensitive Disease: Esophageal cancer [ICD-11: 2B70.1]
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: TE-1 cells; Esophagus; Homo sapiens (Human); CVCL_1759
• In Vitro Model: 293T cells; Breast; Homo sapiens (Human); CVCL_0063
• In Vitro Model: EC9706 cells; Esophagus; Homo sapiens (Human); CVCL_E307
• In Vitro Model: KYSE150 cells; Esophagus; Homo sapiens (Human); CVCL_1348
• In Vitro Model: EC109 cells; Esophagus; Homo sapiens (Human); CVCL_6898
• In Vitro Model: EC1 cells; Esophagus; Homo sapiens (Human); CVCL_DC74
• In Vitro Model: HEEC cells; Esophagus; Homo sapiens (Human); N.A.
• In Vivo Model: Nude mouse xenograft model; Mus musculus
• Experiment for Molecule Alteration: Western blot analysis
• Experiment for Drug Resistance: MTT assay
• Mechanism Description: miroRNA-127-3p targets XRCC3 to enhance the chemosensitivity of esophageal cancer cells to a novel phenanthroline-dione derivative.

References

• Ref 1: MiroRNA-127-3p targets XRCC3 to enhance the chemosensitivity of esophageal cancer cells to a novel phenanthroline-dione derivative. Int J Biochem Cell Biol. 2016 Oct;79:158-167. doi: 10.1016/j.biocel.2016.08.026. Epub 2016 Aug 30.