Drug Information

Drug (ID: DG00022) and It's Reported Resistant Information

Name	Copper
Synonyms	Cu-7; Paragard T 380a; Tatum-t Click to Show/Hide
Indication	In total 1 Indication(s) Contraceptive management [ICD-11: QA21] Approved [1]
Structure
Drug Resistance Disease(s)	*Disease(s) with Resistance Information Validated by in-vivo* Model for This Drug** (1 diseases) HIV associated with tuberculosis [ICD-11: 1C60] [1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
Formula	Cu
IsoSMILES	[Cu]
InChI	1S/Cu
InChIKey	RYGMFSIKBFXOCR-UHFFFAOYSA-N
PubChem CID	23978
ChEBI ID	CHEBI:28694
TTD Drug ID	D01WMJ
DrugBank ID	DB09130

Type(s) of Resistant Mechanism of This Drug

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-01: Infectious/parasitic diseases

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HIV associated with tuberculosis [ICD-11: 1C60]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Copper-translocating P-type ATPase (COPA)			[1]
Resistant Disease	HIV-infected patients with tuberculosis [ICD-11: 1C60.0]		Disease Info
Molecule Alteration	Expression	Up-regulation	Molecule Info
Experimental Note	Discovered Using In-vivo Testing Model
Cell Pathway Regulation	Cell growth	Inhibition	hsa05200
In Vitro Model	Mycobacterium smegmatis mc2155		246196
	Mycobacterium smegmatis mc2155-Cu		246196
Experiment for Molecule Alteration	qPCR
Experiment for Drug Resistance	MIC assay
Mechanism Description	Quantitative proteomics was carried out to find differentially expressed proteins between mc2155 and mc2155-Cu. Among 345 differentially expressed proteins, copper-translocating P-type ATPase was up-regulated, while all other ABC transporters were down-regulated in mc2155-Cu, suggesting copper-translocating P-type ATPase plays a crucial role in copper resistance. Results also indicated that the down-regulation of metabolic enzymes and decreases in cellular NAD, FAD, mycothiol, and glutamine levels in mc2155-Cu were responsible for its slowing growth rate as compared to mc2155.

References

Ref 1	Proteomic Analysis of Drug-Resistant Mycobacteria: Co-Evolution of Copper and INH Resistance. PLoS One. 2015 Jun 2;10(6):e0127788. doi: 10.1371/journal.pone.0127788. eCollection 2015.