Disease Information

General Information of the Disease (ID: DIS00559)

• Name: Dermatophytosis
• ICD: ICD-11: 1F28

Type(s) of Resistant Mechanism of This Disease

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Terbinafine

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Key Molecule: Squalene epoxidase (SQLE) [1]

• Resistant Disease: t. indotineae infection [ICD-11: 1F28]
• Resistant Drug: Terbinafine
• Molecule Alteration: Missense mutation; L38HL
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: T. indotineae; 5475
• Experiment for Molecule Alteration: PCR; PCR-ELISA assay; GeneSeq assay
• Experiment for Drug Resistance: In vitro drug susceptibility testing; Resistance testing
• Mechanism Description: Mutations L393S, L393F, F397L, and F397I of the SQLE gene were associated with terbinafine resistance. Resistance to itraconazole could not be explained by mutations in the ERG11B gene.

References

• Ref 1: Trichophyton mentagrophytes ITS Genotype VIII/Trichophyton indotineae Infection and Antifungal Resistance in Bangladesh. J Fungi (Basel). 2024 Nov 5;10(11):768.