Disease Information

General Information of the Disease (ID: DIS00511)
Name
Brain cancer
ICD
ICD-11: 2A00
Resistance Map
Type(s) of Resistant Mechanism of This Disease
  MRAP: Metabolic Reprogramming via Altered Pathways
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Temozolomide
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Metabolic Reprogramming via Altered Pathways (MRAP) Click to Show/Hide
Key Molecule: Sponging microRNAs [1]
Metabolic Type Glucose metabolism
Resistant Disease Diffuse glioma [ICD-11: 2A00.0]
Resistant Drug Temozolomide
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
In Vivo Model TMZ-resistant patients Homo Sapiens
Experiment for
Molecule Alteration		 qRT-PCR
Experiment for
Drug Resistance		 Overall survival assay (OS)
Mechanism Description Exosomal circ_0072083 promoted TMZ resistance via increasing NANOG via regulating miR-1252-5p-mediated degradation and demethylation in glioma.
Key Molecule: Sponging microRNAs [1]
Metabolic Type Glucose metabolism
Resistant Disease Diffuse glioma [ICD-11: 2A00.0]
Resistant Drug Temozolomide
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model U251 cells Brain Homo sapiens (Human) CVCL_0021
U87 cells Brain Homo sapiens (Human) CVCL_0022
Experiment for
Molecule Alteration		 qRT-PCR
Experiment for
Drug Resistance		 IC50 assay
Mechanism Description Exosomal circ_0072083 promoted TMZ resistance via increasing NANOG via regulating miR-1252-5p-mediated degradation and demethylation in glioma.
Key Molecule: Sponging microRNAs [1]
Metabolic Type Glucose metabolism
Resistant Disease Diffuse glioma [ICD-11: 2A00.0]
Resistant Drug Temozolomide
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vivo Model U251 cell xenograft model, U251/TR-sh-NC EXO Mice
Experiment for
Molecule Alteration		 qRT-PCR
Experiment for
Drug Resistance		 Tumor volume assay
Mechanism Description Exosomal circ_0072083 promoted TMZ resistance via increasing NANOG via regulating miR-1252-5p-mediated degradation and demethylation in glioma.
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
  Metabolic Reprogramming via Altered Pathways (MRAP) Click to Show/Hide
Key Molecule: Sponging microRNAs [1]
Metabolic Type Glucose metabolism
Sensitive Disease Diffuse glioma [ICD-11: 2A00.0]
Sensitive Drug Temozolomide
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model U251 cells Brain Homo sapiens (Human) CVCL_0021
U87 cells Brain Homo sapiens (Human) CVCL_0022
Experiment for
Molecule Alteration		 qRT-PCR
Experiment for
Drug Resistance		 IC50 assay
Mechanism Description Exosomal circ_0072083 promoted TMZ resistance via increasing NANOG via regulating miR-1252-5p-mediated degradation and demethylation in glioma.
Key Molecule: Sponging microRNAs [1]
Metabolic Type Glucose metabolism
Sensitive Disease Diffuse glioma [ICD-11: 2A00.0]
Sensitive Drug Temozolomide
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vivo Model U251 cell xenograft model, U251/TR-sh-circ_0072083 EXO Mice
Experiment for
Molecule Alteration		 qRT-PCR
Experiment for
Drug Resistance		 Tumor volume assay
Mechanism Description Exosomal circ_0072083 promoted TMZ resistance via increasing NANOG via regulating miR-1252-5p-mediated degradation and demethylation in glioma.
References
Ref 1 Warburg effect-promoted exosomal circ_0072083 releasing up-regulates NANGO expression through multiple pathways and enhances temozolomide resistance in glioma. J Exp Clin Cancer Res. 2021 May 11;40(1):164.

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