Disease Information

General Information of the Disease (ID: DIS00413)

• Name: Acute lung injury
• ICD: ICD-11: NB32

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Lipopolysaccharide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Cancer susceptibility 9 (CASC9) [1]

• Resistant Disease: Acute lung injury [ICD-11: NB32.3Z]
• Resistant Drug: Lipopolysaccharide
• Molecule Alteration: Down-regulation; Interaction
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: HSAECs; N.A.; N.A.; N.A.
• In Vivo Model: Sepsis rat model; Rattus norvegicus
• Experiment for Molecule Alteration: Knockdown assay; qRT-PCR; Western bloting analysis; Luciferase assay; RIP experiments assay
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: CASC9 protects lung epithelial cells from sepsis-induced injury via regulating miR-195-5p/PDK4 axis.

Key Molecule: Long non-protein coding RNA (A_30_P01029806) [2]

• Resistant Disease: Acute lung injury [ICD-11: NB32.3Z]
• Resistant Drug: Lipopolysaccharide
• Molecule Alteration: Down-regulation; Expression
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vivo Model: ALI mouse model; Mus musculus
• Experiment for Molecule Alteration: Microarray assay
• Experiment for Drug Resistance: CT scan assay
• Mechanism Description: LncRNA A_30_P01029806 and A_30_P01029194, which were down-regulated, were involved in the signaling pathways closely related to ALI.

References

• Ref 1: Down-regulation of lncRNA CASC9 aggravates sepsis-induced acute lung injury by regulating miR-195-5p/PDK4 axisInflamm Res. 2020 Jun;69(6):559-568. doi: 10.1007/s00011-020-01316-2. Epub 2020 Mar 27.
• Ref 2: LncRNA analysis of lung tissues after hUC-MSCs and FTY720 treatment of lipopolysaccharide-induced acute lung injury in mouse modelsInt Immunopharmacol. 2019 Jun;71:68-75. doi: 10.1016/j.intimp.2019.03.017. Epub 2019 Mar 14.