Disease Information

General Information of the Disease (ID: DIS00393)

• Name: Autoimmune disease
• ICD: ICD-11: 4A4Z

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Melatonin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Monocyte chemotactic and activating factor (CCL2) [1]

• Resistant Disease: Autoimmune disease [ICD-11: 4A4Z.0]
• Molecule Alteration: Down-regulation; Expression
• Resistant Drug: Melatonin
• Experimental Note: Identified from the Human Clinical Data
• Experiment for Molecule Alteration: Knockdown assay
• Mechanism Description: The conclusion on a partial mediation by SIRT1 is supported by repeatedly observed inhibitions of melatonin effects by sirtuin inhibitors or knockdown.

References

• Ref 1: Melatonin and inflammation-Story of a double-edged bladeJ Pineal Res. 2018 Nov;65(4):e12525. doi: 10.1111/jpi.12525. Epub 2018 Oct 12.