Disease Information

Drug Resistance Data Categorized by Drug
Approved Drug(s)
5 drug(s) in total
Click to Show/Hide the Full List of Drugs
Fluconazole
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Lanosterol 14-alpha demethylase (CYP51A1) [1]
Resistant Disease Cystic fibrosis [ICD-11: CA25.0]
Resistant Drug Fluconazole
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model S. minutisporum 41687
Experiment for
Molecule Alteration		 Fluorescent reporter assay; GC-MS
Experiment for
Drug Resistance		 Antifungal susceptibility assay; Membrane fluidity assay
Mechanism Description SCFM increases Scedosporium/Lomentospora azole tolerance.Azole resistance is partially due to the efflux pump activity.SCFM leads to decrease in sterol membrane content and increase in membrane fluidity.Scedosporium/Lomentospora species undergo cellular adaptations in SCFM that favours their growth in face of the challenges imposed by azole antifungals.
Key Molecule: Ergosterol [1]
Resistant Disease Cystic fibrosis [ICD-11: CA25.0]
Resistant Drug Fluconazole
 Drug Info 
Molecule Alteration Expression
Down-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model S. minutisporum 41687
Experiment for
Molecule Alteration		 Fluorescent reporter assay; GC-MS
Experiment for
Drug Resistance		 Antifungal susceptibility assay; Membrane fluidity assay
Mechanism Description SCFM increases Scedosporium/Lomentospora azole tolerance.Azole resistance is partially due to the efflux pump activity.SCFM leads to decrease in sterol membrane content and increase in membrane fluidity.Scedosporium/Lomentospora species undergo cellular adaptations in SCFM that favours their growth in face of the challenges imposed by azole antifungals.
  Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Calcium-transporting ATPase type 2C member 1 [1]
Resistant Disease Cystic fibrosis [ICD-11: CA25.0]
Resistant Drug Fluconazole
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model S. minutisporum 41687
Experiment for
Molecule Alteration		 Fluorescent reporter assay; GC-MS
Experiment for
Drug Resistance		 Antifungal susceptibility assay; Membrane fluidity assay
Mechanism Description SCFM increases Scedosporium/Lomentospora azole tolerance.Azole resistance is partially due to the efflux pump activity.SCFM leads to decrease in sterol membrane content and increase in membrane fluidity.Scedosporium/Lomentospora species undergo cellular adaptations in SCFM that favours their growth in face of the challenges imposed by azole antifungals.
Itraconazole
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Lanosterol 14-alpha demethylase (CYP51A1) [1]
Resistant Disease Cystic fibrosis [ICD-11: CA25.0]
Resistant Drug Itraconazole
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model S. minutisporum 41687
Experiment for
Molecule Alteration		 Fluorescent reporter assay; GC-MS
Experiment for
Drug Resistance		 Antifungal susceptibility assay; Membrane fluidity assay
Mechanism Description SCFM increases Scedosporium/Lomentospora azole tolerance.Azole resistance is partially due to the efflux pump activity.SCFM leads to decrease in sterol membrane content and increase in membrane fluidity.Scedosporium/Lomentospora species undergo cellular adaptations in SCFM that favours their growth in face of the challenges imposed by azole antifungals.
Key Molecule: Ergosterol [1]
Resistant Disease Cystic fibrosis [ICD-11: CA25.0]
Resistant Drug Itraconazole
 Drug Info 
Molecule Alteration Expression
Down-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model S. minutisporum 41687
Experiment for
Molecule Alteration		 Fluorescent reporter assay; GC-MS
Experiment for
Drug Resistance		 Antifungal susceptibility assay; Membrane fluidity assay
Mechanism Description SCFM increases Scedosporium/Lomentospora azole tolerance.Azole resistance is partially due to the efflux pump activity.SCFM leads to decrease in sterol membrane content and increase in membrane fluidity.Scedosporium/Lomentospora species undergo cellular adaptations in SCFM that favours their growth in face of the challenges imposed by azole antifungals.
  Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Calcium-transporting ATPase type 2C member 1 [1]
Resistant Disease Cystic fibrosis [ICD-11: CA25.0]
Resistant Drug Itraconazole
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model S. minutisporum 41687
Experiment for
Molecule Alteration		 Fluorescent reporter assay; GC-MS
Experiment for
Drug Resistance		 Antifungal susceptibility assay; Membrane fluidity assay
Mechanism Description SCFM increases Scedosporium/Lomentospora azole tolerance.Azole resistance is partially due to the efflux pump activity.SCFM leads to decrease in sterol membrane content and increase in membrane fluidity.Scedosporium/Lomentospora species undergo cellular adaptations in SCFM that favours their growth in face of the challenges imposed by azole antifungals.
Ketoconazole
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Lanosterol 14-alpha demethylase (CYP51A1) [1]
Resistant Disease Cystic fibrosis [ICD-11: CA25.0]
Resistant Drug Ketoconazole
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model S. minutisporum 41687
Experiment for
Molecule Alteration		 Fluorescent reporter assay; GC-MS
Experiment for
Drug Resistance		 Antifungal susceptibility assay; Membrane fluidity assay
Mechanism Description SCFM increases Scedosporium/Lomentospora azole tolerance.Azole resistance is partially due to the efflux pump activity.SCFM leads to decrease in sterol membrane content and increase in membrane fluidity.Scedosporium/Lomentospora species undergo cellular adaptations in SCFM that favours their growth in face of the challenges imposed by azole antifungals.
Key Molecule: Ergosterol [1]
Resistant Disease Cystic fibrosis [ICD-11: CA25.0]
Resistant Drug Ketoconazole
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model S. minutisporum 41687
Experiment for
Molecule Alteration		 Fluorescent reporter assay; GC-MS
Experiment for
Drug Resistance		 Antifungal susceptibility assay; Membrane fluidity assay
Mechanism Description SCFM increases Scedosporium/Lomentospora azole tolerance.Azole resistance is partially due to the efflux pump activity.SCFM leads to decrease in sterol membrane content and increase in membrane fluidity.Scedosporium/Lomentospora species undergo cellular adaptations in SCFM that favours their growth in face of the challenges imposed by azole antifungals.
  Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Calcium-transporting ATPase type 2C member 1 [1]
Resistant Disease Cystic fibrosis [ICD-11: CA25.0]
Resistant Drug Ketoconazole
 Drug Info 
Molecule Alteration Expression
Down-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model S. minutisporum 41687
Experiment for
Molecule Alteration		 Fluorescent reporter assay; GC-MS
Experiment for
Drug Resistance		 Antifungal susceptibility assay; Membrane fluidity assay
Mechanism Description SCFM increases Scedosporium/Lomentospora azole tolerance.Azole resistance is partially due to the efflux pump activity.SCFM leads to decrease in sterol membrane content and increase in membrane fluidity.Scedosporium/Lomentospora species undergo cellular adaptations in SCFM that favours their growth in face of the challenges imposed by azole antifungals.
Posaconazole
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Lanosterol 14-alpha demethylase (CYP51A1) [1]
Resistant Disease Cystic fibrosis [ICD-11: CA25.0]
Resistant Drug Posaconazole
 Drug Info 
Molecule Alteration Expression
Down-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model S. minutisporum 41687
Experiment for
Molecule Alteration		 Fluorescent reporter assay; GC-MS
Experiment for
Drug Resistance		 Antifungal susceptibility assay; Membrane fluidity assay
Mechanism Description SCFM increases Scedosporium/Lomentospora azole tolerance.Azole resistance is partially due to the efflux pump activity.SCFM leads to decrease in sterol membrane content and increase in membrane fluidity.Scedosporium/Lomentospora species undergo cellular adaptations in SCFM that favours their growth in face of the challenges imposed by azole antifungals.
Key Molecule: Ergosterol [1]
Resistant Disease Cystic fibrosis [ICD-11: CA25.0]
Resistant Drug Posaconazole
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model S. minutisporum 41687
Experiment for
Molecule Alteration		 Fluorescent reporter assay; GC-MS
Experiment for
Drug Resistance		 Antifungal susceptibility assay; Membrane fluidity assay
Mechanism Description SCFM increases Scedosporium/Lomentospora azole tolerance.Azole resistance is partially due to the efflux pump activity.SCFM leads to decrease in sterol membrane content and increase in membrane fluidity.Scedosporium/Lomentospora species undergo cellular adaptations in SCFM that favours their growth in face of the challenges imposed by azole antifungals.
  Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Calcium-transporting ATPase type 2C member 1 [1]
Resistant Disease Cystic fibrosis [ICD-11: CA25.0]
Resistant Drug Posaconazole
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model S. minutisporum 41687
Experiment for
Molecule Alteration		 Fluorescent reporter assay; GC-MS
Experiment for
Drug Resistance		 Antifungal susceptibility assay; Membrane fluidity assay
Mechanism Description SCFM increases Scedosporium/Lomentospora azole tolerance.Azole resistance is partially due to the efflux pump activity.SCFM leads to decrease in sterol membrane content and increase in membrane fluidity.Scedosporium/Lomentospora species undergo cellular adaptations in SCFM that favours their growth in face of the challenges imposed by azole antifungals.
Voriconazole
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Lanosterol 14-alpha demethylase (CYP51A1) [1]
Resistant Disease Cystic fibrosis [ICD-11: CA25.0]
Resistant Drug Voriconazole
 Drug Info 
Molecule Alteration Expression
Down-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model S. minutisporum 41687
Experiment for
Molecule Alteration		 Fluorescent reporter assay; GC-MS
Experiment for
Drug Resistance		 Antifungal susceptibility assay; Membrane fluidity assay
Mechanism Description SCFM increases Scedosporium/Lomentospora azole tolerance.Azole resistance is partially due to the efflux pump activity.SCFM leads to decrease in sterol membrane content and increase in membrane fluidity.Scedosporium/Lomentospora species undergo cellular adaptations in SCFM that favours their growth in face of the challenges imposed by azole antifungals.
Key Molecule: Ergosterol [1]
Resistant Disease Cystic fibrosis [ICD-11: CA25.0]
Resistant Drug Voriconazole
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model S. minutisporum 41687
Experiment for
Molecule Alteration		 Fluorescent reporter assay; GC-MS
Experiment for
Drug Resistance		 Antifungal susceptibility assay; Membrane fluidity assay
Mechanism Description SCFM increases Scedosporium/Lomentospora azole tolerance.Azole resistance is partially due to the efflux pump activity.SCFM leads to decrease in sterol membrane content and increase in membrane fluidity.Scedosporium/Lomentospora species undergo cellular adaptations in SCFM that favours their growth in face of the challenges imposed by azole antifungals.
  Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Calcium-transporting ATPase type 2C member 1 [1]
Resistant Disease Cystic fibrosis [ICD-11: CA25.0]
Resistant Drug Voriconazole
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model S. minutisporum 41687
Experiment for
Molecule Alteration		 Fluorescent reporter assay; GC-MS
Experiment for
Drug Resistance		 Antifungal susceptibility assay; Membrane fluidity assay
Mechanism Description SCFM increases Scedosporium/Lomentospora azole tolerance.Azole resistance is partially due to the efflux pump activity.SCFM leads to decrease in sterol membrane content and increase in membrane fluidity.Scedosporium/Lomentospora species undergo cellular adaptations in SCFM that favours their growth in face of the challenges imposed by azole antifungals.
References
Ref 1 Elucidating the augmented resistance profile of Scedosporium/Lomentospora species to azoles in a cystic fibrosis mimic environment. J Antimicrob Chemother. 2025 Jan 3;80(1):106-115.

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