Disease Information

General Information of the Disease (ID: DIS00299)

• Name: Peripheral arterial disease
• ICD: ICD-11: BD4Z

Type(s) of Resistant Mechanism of This Disease

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Clopidogrel

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Key Molecule: Cytochrome P450 family 2 subfamily C member 19 (CYP2C19) [1]

• Resistant Disease: Peripheral arterial disease [ICD-11: BD4Z.0]
• Molecule Alteration: SNP; .
• Resistant Drug: Clopidogrel
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Whole blood; .
• Experiment for Drug Resistance: VerifyNow P2Y12 assay
• Mechanism Description: Clopidogrel is a pro-drug requiring cytochrome P450 (CYP) 2C19 enzyme to be oxidised to its active form.CYP 2C19 genetic polymorphism may result clopidogrel resistance.

References

• Ref 1: CYP2C19 Polymorphism is Associated With Amputation Rates in Patients Taking Clopidogrel After Endovascular Intervention for Critical Limb Ischaemia .Eur J Vasc Endovasc Surg. 2019 Sep;58(3):373-382. doi: 10.1016/j.ejvs.2019.02.011. Epub 2019 Aug 5. 10.1016/j.ejvs.2019.02.011