Disease Information

General Information of the Disease (ID: DIS00252)

• Name: Schizophrenia
• ICD: ICD-11: 6A20

Type(s) of Resistant Mechanism of This Disease

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Olanzapine

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: Mitogen-activated protein kinase 8 (MAPK8) [1]

• Resistant Disease: Schizophrenia [ICD-11: 6A20.0]
• Resistant Drug: Olanzapine
• Molecule Alteration: Function; Activation
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vivo Model: Female C57BL/6J mouse model; Mus musculus
• Experiment for Molecule Alteration: Western blot analysis; RT-qPCR
• Experiment for Drug Resistance: Flow cytometry
• Mechanism Description: JNK downregulation improves olanzapine-induced insulin resistance by suppressing IRS1Ser307 phosphorylation and reducing inflammation.

References

• Ref 1: JNK downregulation improves olanzapine-induced insulin resistance by suppressing IRS1(Ser307) phosphorylation and reducing inflammation .Biomed Pharmacother. 2021 Oct;142:112071. doi: 10.1016/j.biopha.2021.112071. Epub 2021 Aug 26. 10.1016/j.biopha.2021.112071