Disease Information

General Information of the Disease (ID: DIS00216)

• Name: Colorectal peritoneal carcinomatosis
• ICD: ICD-11: 2D91

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Fluorouracil

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Adipocytic Glutamine Synthetase (GS) [1]

• Resistant Disease: Colorectal peritoneal carcinomatosis [CD-11: 2D91.Y]
• Molecule Alteration: Expression; Up-regulation
• Resistant Drug: Fluorouracil
• Experimental Note: Identified from the Human Clinical Data
• Cell Pathway Regulation: mTOR signaling pathway; Activation; hsa04150
• In Vitro Model: B16 cells; Skin; Homo sapiens (Human); CVCL_F936
• In Vitro Model: HCT-116 cells; Colon; Homo sapiens (Human); N.A.
• In Vitro Model: CT26 cells; Colon; Mus musculus (Mouse); CVCL_7254
• In Vitro Model: MC38 cells; Colon; Mus musculus (Mouse); CVCL_B288
• In Vitro Model: SW-480 cells; Colon; Homo sapiens (Human); CVCL_0546
• In Vitro Model: 3T3-L1 cells; Nasopharynx; Mus musculus (Mouse); CVCL_0123
• In Vivo Model: BALB/c mice xenograft model; Mus musculus
• Experiment for Molecule Alteration: qRT-PCR; Western blotting assay
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: Adipocytic Glutamine Synthetase Upregulation via Altered Histone Methylation Promotes 5FU Chemoresistance in Peritoneal Carcinomatosis of Colorectal Cancer

References

• Ref 1: Adipocytic Glutamine Synthetase Upregulation via Altered Histone Methylation Promotes 5FU Chemoresistance in Peritoneal Carcinomatosis of Colorectal Cancer .Front Oncol. 2021 Oct 12;11:748730. doi: 10.3389/fonc.2021.748730. eCollection 2021. 10.3389/fonc.2021.748730