Molecule Information

General Information of the Molecule (ID: Mol02166)

• Name: Metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) (Malat1) ,Mus musculus
• Synonyms: Malat1
• Molecule Type: LncRNA
• Gene Name: Malat1
• Gene ID: 72289
• Location: chr19:5,845,717-5,852,704[-]
• Ensembl ID: ENSMUSG00000092341

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Bupivacaine

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Neurotoxicity [1]

• Resistant Disease: Neurotoxicity [ICD-11: NE61.0]
• Resistant Drug: Bupivacaine
• Molecule Alteration: Up-regulation; Interaction
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: SH-SY5Y cells; Abdomen; Homo sapiens (Human); CVCL_0019
• Experiment for Molecule Alteration: Western bloting analysis; Dual luciferase assay; Knockdown assay
• Experiment for Drug Resistance: CCK8 assay; Caspase-3 activity assay
• Mechanism Description: Knockdown of LncRNA MALAT1 alleviates bupivacaine-induced neurotoxicity via the miR-101-3p/PDCD4 axis.

Investigative Drug(s) 1 drug(s) in total

Hydrochloride

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Sepsis [1]

• Resistant Disease: Sepsis [ICD-11: 1G40.0]
• Resistant Drug: Hydrochloride
• Molecule Alteration: Up-regulation; Interaction
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: RAW 264.7; Ascites; Mus musculus (Mouse); CVCL_0493
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: CellTiter assay
• Mechanism Description: Hsa-miR-346 plays a role in the development of sepsis by downregulating SMAD3 expression and is negatively regulated by LncRNA MALAT1.

References

• Ref 1: Knockdown of lncRNA MALAT1 alleviates bupivacaine-induced neurotoxicity via the miR-101-3p/PDCD4 axisLife Sci. 2019 Sep 1;232:116606. doi: 10.1016/j.lfs.2019.116606. Epub 2019 Jun 27.