Drug Information

Drug (ID: DG01846) and It's Reported Resistant Information

Name	Hydrochloride
Synonyms	(E)-SIS3; SMAD3; (E)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenylpyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one;hydrochloride; DS-015902 Click to Show/Hide
Indication	In total 1 Indication(s) Attention deficit hyperactivity disorder [ICD-11: 6A05] Phase 3 [1]
Structure
Drug Resistance Disease(s)	Disease(s) with Clinically Reported Resistance for This Drug (1 diseases) Sepsis [ICD-11: 1G40] [1]
Target	Norepinephrine transporter (NET)	SC6A2_HUMAN	[1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
Formula	5
IsoSMILES	CN1C(=C(C2=C1N=CC=C2)C=CC(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5.Cl
InChI	InChI=1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H
InChIKey	CDKIEBFIMCSCBB-UHFFFAOYSA-N
PubChem CID	69797958

Type(s) of Resistant Mechanism of This Drug

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-01: Infectious/parasitic diseases

Click to Show/Hide the Resistance Disease of This Class

Sepsis [ICD-11: 1G40]

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: Metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) (Malat1)				[1]
Molecule Alteration	Up-regulation		Interaction	Molecule Info
Resistant Disease	Sepsis [ICD-11: 1G40.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	RAW 264.7	Ascites	Mus musculus (Mouse)	CVCL_0493
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	CellTiter assay
Mechanism Description	Hsa-miR-346 plays a role in the development of sepsis by downregulating SMAD3 expression and is negatively regulated by LncRNA MALAT1.

References

Ref 1	Knockdown of lncRNA MALAT1 alleviates bupivacaine-induced neurotoxicity via the miR-101-3p/PDCD4 axisLife Sci. 2019 Sep 1;232:116606. doi: 10.1016/j.lfs.2019.116606. Epub 2019 Jun 27.