Disease Information

General Information of the Disease (ID: DIS00414)

Type(s) of Resistant Mechanism of This Disease

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

2 drug(s) in total

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Bupivacaine

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: Metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) (Malat1)				[1]
Resistant Disease	Neurotoxicity [ICD-11: NE61.0]
Molecule Alteration	Up-regulation		Interaction	Molecule Info
Resistant Drug	Bupivacaine			Drug Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	SH-SY5Y cells	Abdomen	Homo sapiens (Human)	CVCL_0019
Experiment for Molecule Alteration	Western bloting analysis; Dual luciferase assay; Knockdown assay
Experiment for Drug Resistance	CCK8 assay; Caspase-3 activity assay
Mechanism Description	Knockdown of LncRNA MALAT1 alleviates bupivacaine-induced neurotoxicity via the miR-101-3p/PDCD4 axis.

Hydrogen peroxide

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: Long non-protein coding RNA (LOC284930)				[2]
Resistant Disease	Neurotoxicity [ICD-11: NE61.0]
Molecule Alteration	Down-regulation		Expression	Molecule Info
Resistant Drug	Hydrogen peroxide			Drug Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	SH-SY5Y cells	Abdomen	Homo sapiens (Human)	CVCL_0019
Experiment for Molecule Alteration	Overexpression assay; Knockdown assay
Experiment for Drug Resistance	CCK8 assay; LDH assay; Caspase-3 activity assay
Mechanism Description	Lnc-EPIC1 downregulation mediates H2O2-induced neuronal cell death.

References

Ref 1	Knockdown of lncRNA MALAT1 alleviates bupivacaine-induced neurotoxicity via the miR-101-3p/PDCD4 axisLife Sci. 2019 Sep 1;232:116606. doi: 10.1016/j.lfs.2019.116606. Epub 2019 Jun 27.
Ref 2	LncRNA EPIC1 downregulation mediates hydrogen peroxide-induced neuronal cell injuryAging (Albany NY). 2019 Dec 8;11(23):11463-11473. doi: 10.18632/aging.102545. Epub 2019 Dec 8.