Molecule Information

General Information of the Molecule (ID: Mol02014)

Name	Multidrug resistance protein MdtE (MDTE) ,Trichomonas vaginalis
Synonyms	TVAG_572140 Click to Show/Hide
Molecule Type	Protein
Gene Name	MDTE
Gene ID	4741312
Sequence	MSNNIKLVVVGDGAVGKTCLLVVYARNEFPSEYVPTVFDNYTAKVKIDDTLYPVQLWDTA GQEELENIRTLSYQNTSVFLLCFSVTTPTTFDNLTTVWIPEIKRYVKNPEILLIGTKADL RNDEQTLKNLEADGKAPITLEQAQQKAKEIGAIAYCECSALKNEGVREAFDKAINHIIEK DNGGCCHLI Click to Show/Hide
Uniprot ID	A2GGN6_TRIVA
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Parabasalia Class: . Order: Trichomonadida Family: Trichomonadidae Genus: Trichomonas Species: Trichomonas vaginalis

Type(s) of Resistant Mechanism of This Molecule

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Metronidazole

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Disease Class: Trichomoniasis			[1]
Resistant Disease	Trichomoniasis [ICD-11: 1A92.0]		Disease Info
Resistant Drug	Metronidazole		Drug Info
Molecule Alteration	Expression	Up-regulation
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	Trichomonas vaginalis ATCC 30001		5722
	Trichomonas vaginalis ATCC 30236		5722
	Trichomonas vaginalis ATCC50148		5722
	Trichomonas vaginalis ATCC 50142		5722
	Trichomonas vaginalis ATCC 50143		5722
	Trichomonas vaginalis ATCC 30238		5722
Experiment for Molecule Alteration	Gene sequencing assay
Experiment for Drug Resistance	Trypan blue exclusion assay
Mechanism Description	Comparative transcriptomes analysis identified that several putative drug-resistant genes were exclusively upregulated in different MTZ-R strains, such as ATP-binding cassette (ABC) transporters and multidrug resistance pumps.

References

Ref 1	Dissecting the Transcriptomes of Multiple Metronidazole-Resistant and Sensitive Trichomonas vaginalis Strains Identified Distinct Genes and Pathways Associated with Drug Resistance and Cell Death .Biomedicines. 2021 Dec 2;9(12):1817. doi: 10.3390/biomedicines9121817. 10.3390/biomedicines9121817