General Information of the Molecule (ID: Mol02014)
Name
Multidrug resistance protein MdtE (MDTE) ,Trichomonas vaginalis
Synonyms
TVAG_572140
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Molecule Type
Protein
Gene Name
MDTE
Gene ID
4741312
Sequence
MSNNIKLVVVGDGAVGKTCLLVVYARNEFPSEYVPTVFDNYTAKVKIDDTLYPVQLWDTA
GQEELENIRTLSYQNTSVFLLCFSVTTPTTFDNLTTVWIPEIKRYVKNPEILLIGTKADL
RNDEQTLKNLEADGKAPITLEQAQQKAKEIGAIAYCECSALKNEGVREAFDKAINHIIEK
DNGGCCHLI
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Uniprot ID
A2GGN6_TRIVA
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Kingdom: N.A.
Phylum: Parabasalia
Class: .
Order: Trichomonadida
Family: Trichomonadidae
Genus: Trichomonas
Species: Trichomonas vaginalis
Type(s) of Resistant Mechanism of This Molecule
  IDUE: Irregularity in Drug Uptake and Drug Efflux
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Metronidazole
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Disease Class: Trichomoniasis [1]
Resistant Disease Trichomoniasis [ICD-11: 1A92.0]
Resistant Drug Metronidazole
Molecule Alteration Expression
Up-regulation
Experimental Note Discovered Using In-vivo Testing Model
In Vitro Model Trichomonas vaginalis ATCC 30001 5722
Trichomonas vaginalis ATCC 30236 5722
Trichomonas vaginalis ATCC50148 5722
Trichomonas vaginalis ATCC 50142 5722
Trichomonas vaginalis ATCC 50143 5722
Trichomonas vaginalis ATCC 30238 5722
Experiment for
Molecule Alteration
Gene sequencing assay
Experiment for
Drug Resistance
Trypan blue exclusion assay
Mechanism Description Comparative transcriptomes analysis identified that several putative drug-resistant genes were exclusively upregulated in different MTZ-R strains, such as ATP-binding cassette (ABC) transporters and multidrug resistance pumps.
References
Ref 1 Dissecting the Transcriptomes of Multiple Metronidazole-Resistant and Sensitive Trichomonas vaginalis Strains Identified Distinct Genes and Pathways Associated with Drug Resistance and Cell Death .Biomedicines. 2021 Dec 2;9(12):1817. doi: 10.3390/biomedicines9121817. 10.3390/biomedicines9121817

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