Disease Information

General Information of the Disease (ID: DIS00151)
Name
Trichomoniasis
ICD
ICD-11: 1A92
Resistance Map
Type(s) of Resistant Mechanism of This Disease
  IDUE: Irregularity in Drug Uptake and Drug Efflux
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Metronidazole
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: ABC transporter family protein (ABC) [1]
Resistant Disease Trichomoniasis [ICD-11: 1A92.0]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Resistant Drug Metronidazole
 Drug Info 
Experimental Note Discovered Using In-vivo Testing Model
In Vitro Model Trichomonas vaginalis ATCC 30001 5722
Trichomonas vaginalis ATCC 30236 5722
Trichomonas vaginalis ATCC50148 5722
Trichomonas vaginalis ATCC 50142 5722
Trichomonas vaginalis ATCC 50143 5722
Trichomonas vaginalis ATCC 30238 5722
Experiment for
Molecule Alteration		 Gene sequencing assay
Experiment for
Drug Resistance		 Trypan blue exclusion assay
Mechanism Description Comparative transcriptomes analysis identified that several putative drug-resistant genes were exclusively upregulated in different MTZ-R strains, such as ATP-binding cassette (ABC) transporters and multidrug resistance pumps.
Key Molecule: Multidrug resistance protein MdtE (MDTE) [1]
Resistant Disease Trichomoniasis [ICD-11: 1A92.0]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Resistant Drug Metronidazole
 Drug Info 
Experimental Note Discovered Using In-vivo Testing Model
In Vitro Model Trichomonas vaginalis ATCC 30001 5722
Trichomonas vaginalis ATCC 30236 5722
Trichomonas vaginalis ATCC50148 5722
Trichomonas vaginalis ATCC 50142 5722
Trichomonas vaginalis ATCC 50143 5722
Trichomonas vaginalis ATCC 30238 5722
Experiment for
Molecule Alteration		 Gene sequencing assay
Experiment for
Drug Resistance		 Trypan blue exclusion assay
Mechanism Description Comparative transcriptomes analysis identified that several putative drug-resistant genes were exclusively upregulated in different MTZ-R strains, such as ATP-binding cassette (ABC) transporters and multidrug resistance pumps.
References
Ref 1 Dissecting the Transcriptomes of Multiple Metronidazole-Resistant and Sensitive Trichomonas vaginalis Strains Identified Distinct Genes and Pathways Associated with Drug Resistance and Cell Death .Biomedicines. 2021 Dec 2;9(12):1817. doi: 10.3390/biomedicines9121817. 10.3390/biomedicines9121817

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