Molecule Information

General Information of the Molecule (ID: Mol01090)

Name	Sterol 14-alpha demethylase cyp51A (CYP51A) ,Aspergillus niger
Synonyms	ABL_04779 Click to Show/Hide
Molecule Type	Protein
Gene Name	ABL_04779
Sequence	MAAIAPNPLNAPDTAVSGQSDCQHHWSLAWFDTLSKGSPSGLIRLRNHREQCLLPLLTVF ANHCSGWTDVAQCQGHEPTTTYSFDVLLLTFSFTNTFPINWSFFLPTVASRMAYLAVAGA YAFAALLVAIVLNVARQLLVRNEKEPPVVFHWIPFLGSTISYGMDPYAFFFSCRKKYGDI FTFVLLGKKTTVYLGVQGNDFILNGKLKDVSAEEVYSPLTTPVFGSDVVYDCPNSKLMEQ KKFIKFGLTQAALESHVQLIEKETLDYLRDSPRFNGASGVIDIPAAMAEITIYTAARALQ GEEVRKKLTAEFAELYHDLDKGFSPINFMLPWAPLPHNRKRDAAHARMREIYTDIINERR KNPDEEKSDMIWNLMHCTYKNGQPVPDKEIAHMMITLLMAGQHSSSSISSWIMLRLASEP QVLEELYQEQLTSLSNRNGVFEPLQYQDLDKLPLLQSVIKETLRIHSSIHSIMRKVKNPL PVPGTSYVIPEDRVLLASPGVTALSDEYFPNATRWDPHRWENQPDKEEEGEMVDYGYGSV SKGTASPYLPFGAGRHRCIGEKFAYVNLGVIIATIVRHLKLFNVDGRKGVPGTDYSTLFS GPLKPAIVGWERRIQDNSKGSLN Click to Show/Hide
Uniprot ID	A0A100IIZ2_ASPNG
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Fungi Phylum: Ascomycota Class: Eurotiomycetes Order: Eurotiales Family: Aspergillaceae Genus: Aspergillus Species: Aspergillus niger

Type(s) of Resistant Mechanism of This Molecule

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Posaconazole

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)		Click to Show/Hide
Disease Class: Aspergillus niger infection			[1]
Resistant Disease	Aspergillus niger infection [ICD-11: 1F20.3]		Disease Info
Resistant Drug	Posaconazole		Drug Info
Molecule Alteration	Missense mutation	p.R228Q
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Aspergillus niger strain		5061
Experiment for Molecule Alteration	PCR amplification and sequence analysis
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	Amino acid changes in ERG11 may contribute to Candida albicans emerging posaconazole resistance.

References

Ref 1	Species Distribution and In Vitro Azole Susceptibility of Aspergillus Section Nigri Isolates from Clinical and Environmental Settings. J Clin Microbiol. 2016 Sep;54(9):2365-72. doi: 10.1128/JCM.01075-16. Epub 2016 Jul 13.