Molecule Information

General Information of the Molecule (ID: Mol01089)

Name	Sterol 14-alpha demethylase cyp51A (CYP51A) ,Aspergillus terreus
Synonyms	ATEIFO6365_0007029700; ATETN484_0009029700 Click to Show/Hide
Molecule Type	Protein
Gene Name	ATEIFO6365_0007029700
Sequence	MIMSLLTITSYSAVGILALIAWNVIRQLLFQNKSEPPVVFHWIPFLGSTISYGIDPYAFF ASCRQKYGDIFTFILLGQKTTVYLGVQGNEFILNGKLKDVNAEEVYSPLTTPVFGSDVVY DCPNAKLMEQKKFIKYGLTQAALESHVQLIEREVLDYLRTSPNFHGASGVVDISAAMAEL TIFTAGRALQGEEVRRKLTAEFADLYHDLDKGFTPINFMLPWAPLPHNRKRDAAHARMRA IYMDIIRERRAHKNPDQGEAGSDSDMIWNLMRCTYKDGRPVPDKEIAHMMITLLMAGQHS SSSISAWIFLRLASEPRVLEELYQEQVASLGKPDADGAFPPLQFRDLDRLPLHQNVVKET LRLHSSIHSIMRKVKNPLPVPGTPYVVPTSHVLLASPGVTATSDEYFPNASRWDPHRWEN HAEPDDDDGEMVDYGYGRVSKGTASPYLPFGGGRHRCIGEKFAYINLGVIVATVVRHLKL FNVDGRKGVPPTDYSSLFSGPLKPAIIGWERRFPTA Click to Show/Hide
Uniprot ID	A0A5M3Z4K7_ASPTE
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Fungi Phylum: Ascomycota Class: Eurotiomycetes Order: Eurotiales Family: Aspergillaceae Genus: Aspergillus Species: Aspergillus terreus

Type(s) of Resistant Mechanism of This Molecule

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Itraconazole

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)		Click to Show/Hide
Disease Class: Chronic noninvasive aspergillosis			[1]
Resistant Disease	Chronic noninvasive aspergillosis [ICD-11: 1F20.4]		Disease Info
Resistant Drug	Itraconazole		Drug Info
Molecule Alteration	Missense mutation	p.M217I
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Aspergillus terreus strain		33178
Experiment for Molecule Alteration	DNA sequencing assay
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	In vivo emergence of Aspergillus terreus with reduced azole susceptibility which is related to Cyp51a M217I alteration.

References

Ref 1	In vivo emergence of Aspergillus terreus with reduced azole susceptibility and a Cyp51a M217I alteration. J Infect Dis. 2012 Sep 15;206(6):981-5. doi: 10.1093/infdis/jis442. Epub 2012 Jul 10.