Molecule Information

General Information of the Molecule (ID: Mol01006)

Name	Mitochondrial protoheme IX farnesyltransferase (COX10) ,Aspergillus fumigatus
Synonyms	Heme O synthase; AFUA_4G08340 Click to Show/Hide
Molecule Type	Protein
Gene Name	cox10
Gene ID	3509179
Sequence	MIYLRSSLLRSGLARDPARLCSQCFSRLSPSRRPVAVRSFFSSSRLRAGIADHESTPSTV QKTYFSANRTADGLLASLSAVNSSPRSIADNALSQGAASSESITSQSTSQELPHRRRKRL KEEAAKNNAAETELPPDASSQLSTLSSALPATSLRRKLAAFLALTKPRLSFLIVLTTTSA YGMYPISSLLTLDPSMTPLPTLSTSTLTFLYLTTGTFLSSCSANTLNMLLEPKYDALMSR TRNRPLVRGLLSRRAAVLFAIATAAAGLGLLYIGTNPTTTALSASNICLYAFVYTPLKRI SVINTWVGAVVGGIPPLMGWTAAAGQTATTGHDSWRDMLFSKDSIGGWLLGGILFAWQFP HFNALSYMIREEYKAAGYRMLAWTNPAANARVALRYSLLMFPFSVGLWWVGVVGNGFLVG STAANGWLVKEAYKFWRHQGANGSARRLFWASIWQLPILLVGGLVTKKGLWDGVWNNVFG QPVEDEDDYLWEDEDEVAEAERKMIPAKTSSS Click to Show/Hide
Function	Converts protoheme IX and farnesyl diphosphate to heme O. Click to Show/Hide
Uniprot ID	COX10_ASPFU
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Fungi Phylum: Ascomycota Class: Eurotiomycetes Order: Eurotiales Family: Aspergillaceae Genus: Aspergillus Species: Aspergillus fumigatus

Type(s) of Resistant Mechanism of This Molecule

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

Click to Show/Hide the Full List of Drugs

Itraconazole

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)		Click to Show/Hide
Disease Class: Aspergillus fumigatus infection			[1]
Resistant Disease	Aspergillus fumigatus infection [ICD-11: 1F20.2]		Disease Info
Resistant Drug	Itraconazole		Drug Info
Molecule Alteration	Missense mutation	p.R243Q
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Aspergillus fumigatus strain		746128
Experiment for Molecule Alteration	NGS sequencing assay
Experiment for Drug Resistance	HPLC analysis
Mechanism Description	Through next-generation sequencing (NGS), we successfully identified a new mutation (R243Q substitution) conferring azole resistance in the putative A. fumigatus farnesyltransferase Cox10 (AfCox10) (AFUB_065450). High-performance liquid chromatography (HPLC) analysis verified that the decreased absorption of itraconazole in related Afcox10 mutants is the primary reason for itraconazole resistance.

References

Ref 1	Screening and Characterization of a Non-cyp51A Mutation in an Aspergillus fumigatus cox10 Strain Conferring Azole Resistance. Antimicrob Agents Chemother. 2016 Dec 27;61(1):e02101-16. doi: 10.1128/AAC.02101-16. Print 2017 Jan.