Molecule Information

General Information of the Molecule (ID: Mol00977)

Name	Hydrolase (HYDE) ,Salmonella enterica serovar Typhimurium
Synonyms	ELS01_26210; G0M02_24435; G0M02_24760 Click to Show/Hide
Molecule Type	Protein
Gene Name	ELS01_26210
Sequence	MPVLFRVKVIPLVLLLAMIFAFLLNWPILLHFYEILSHLEHVKIGFVISIPFVLVAALNV VFMPFSVRFLLKPFFALLFITGSLVSYSTLKYKVMFDQTMIQNIIETNPQEAHSYLNGSI IIWFVFTGILPAILLFSIKIQYPEKWYKGIAYRLLSVLASLSLIAGVAALYYQDYASVGR NNSTLNKEIIPANYAYSTFQYVKDTYFTTKVPFQTLGNDAKRVVAHEKPTLMFLVIGETA RSQNFSMNGYSRDTNAFTSKSGGVISFKNMHSCGTATAISVPCMFSNMNRTEYDSKKASN SENFLDIVQKTGVSLLWKENDGGCKGVCSRIPTVEIKPSDNPKLCDGKTCHDEVMLENLD DEIAKMPGDKLVAFHIIGSHGPTYYLRYPAEHRHFMPECARSDIENCTQEQLVNTYDNTL RYTDYVLAEMIEKLKNYSDQYNTVLLYVSDHGESLGESGLYLHGTPYKLAPDQQTHIPMQ VWMSPGFIAGKHINMSCLENNAAKKSYSHDNLFSSILGLWDVSTSVYNPDRDLFRECRG Click to Show/Hide
Uniprot ID	A0A1I9W690_SALTM
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Salmonella Species: Salmonella enterica subsp. enterica serovar Typhimurium

Type(s) of Resistant Mechanism of This Molecule

DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Colistin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Drug Inactivation by Structure Modification (DISM)		Click to Show/Hide
Disease Class: Salmonella enterica infection			[1]
Resistant Disease	Salmonella enterica infection [ICD-11: 1A09.0]		Disease Info
Resistant Drug	Colistin		Drug Info
Molecule Alteration	Expression	Up-regulation
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli NEB5alpha		562
Experiment for Molecule Alteration	In silico EMBOSS Transeq assay
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	Mcr-1 is a phosphoethanolamine transferase that modifies cell membrane lipid A head groups with a phosphoethanolamine residue, reducing affinity to colistin.

References

Ref 1	Identification of Novel Mobilized Colistin Resistance Gene mcr-9 in a Multidrug-Resistant, Colistin-Susceptible Salmonella enterica Serotype Typhimurium Isolate. mBio. 2019 May 7;10(3):e00853-19. doi: 10.1128/mBio.00853-19.