Molecule Information

General Information of the Molecule (ID: Mol00959)

• Name: Erythromycin resistance protein (ERM33) ,Staphylococcus sciuri
• Synonyms: Macrolide-lincosamide-streptogramin B resistance protein; rRNA adenine N-6-methyltransferase; erm33
• Molecule Type: Protein
• Gene Name: erm(33)
• Sequence:
  MNKKNIKDSQNFITSKRNIDKIMTNISLNEHDNIFEIGSGKGHFTLELVQRCNFVTAIEI
  DHKLCKTTENKLVDHDNFQVLNKDILQFKFPKNQSYNIFGNIPYNISTDIVKRITFESQA
  KYSYLIVEKGFAKRLQNLQRALGLLLMVEMDIKMLKKVPPLYFHPKPSVDSVLIVLERHQ
  PLISKKDYKKYRSFVYKWVNREYRVLFTKNQFRQALKHANVTNINKLSKEQFLSIFNSYK
  LFH
• Function: This protein produces a dimethylation of the adenine residue at position 2085 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics.
• Uniprot ID: Q8KLN5_MAMSC

Kingdom: N.A.
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Staphylococcaceae
Genus: Mammaliicoccus
Species: Mammaliicoccus sciuri

Type(s) of Resistant Mechanism of This Molecule

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Macrolides

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Disease Class: Staphylococcus sciuri infection [1]

• Resistant Disease: Staphylococcus sciuri infection [ICD-11: 1B54.1]
• Resistant Drug: Macrolides
• Molecule Alteration: Expression; Gene recombination
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Staphylococcus sciuri plasmid pSCFS1; 1296
• Experiment for Molecule Alteration: Sequence analysis
• Experiment for Drug Resistance: MIC assay
• Mechanism Description: Staphylococcus sciuri Gene erm(33), Encoding Inducible Resistance to Macrolides, Lincosamides, and Streptogramin B Antibiotics, Is a Product of Recombination between erm(C) and erm(A).

Clinical Trial Drug(s) 1 drug(s) in total

Pristinamycin IA

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Disease Class: Staphylococcus sciuri infection [1]

• Resistant Disease: Staphylococcus sciuri infection [ICD-11: 1B54.1]
• Resistant Drug: Pristinamycin IA
• Molecule Alteration: Expression; Gene recombination
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Staphylococcus sciuri plasmid pSCFS1; 1296
• Experiment for Molecule Alteration: Sequence analysis
• Experiment for Drug Resistance: MIC assay
• Mechanism Description: Staphylococcus sciuri Gene erm(33), Encoding Inducible Resistance to Macrolides, Lincosamides, and Streptogramin B Antibiotics, Is a Product of Recombination between erm(C) and erm(A).

Investigative Drug(s) 1 drug(s) in total

Lincosamides

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Disease Class: Staphylococcus sciuri infection [1]

• Resistant Disease: Staphylococcus sciuri infection [ICD-11: 1B54.1]
• Resistant Drug: Lincosamides
• Molecule Alteration: Expression; Gene recombination
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Staphylococcus sciuri plasmid pSCFS1; 1296
• Experiment for Molecule Alteration: Sequence analysis
• Experiment for Drug Resistance: MIC assay
• Mechanism Description: Staphylococcus sciuri Gene erm(33), Encoding Inducible Resistance to Macrolides, Lincosamides, and Streptogramin B Antibiotics, Is a Product of Recombination between erm(C) and erm(A).

References

• Ref 1: Staphylococcus sciuri gene erm(33), encoding inducible resistance to macrolides, lincosamides, and streptogramin B antibiotics, is a product of recombination between erm(C) and erm(A). Antimicrob Agents Chemother. 2002 Nov;46(11):3621-3. doi: 10.1128/AAC.46.11.3621-3623.2002.