Drug Information

Drug (ID: DG00460) and It's Reported Resistant Information

Name	Lincosamides
Synonyms	Lincosamides; D055231000 Click to Show/Hide
Structure
Drug Resistance Disease(s)	Disease(s) with Clinically Reported Resistance for This Drug (1 diseases) Staphylococcus meningitis [ICD-11: 1B54] [1]
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Formula	C36H67ClN4O11S2
IsoSMILES	CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@@H](C)O.CCC[C@@H]1C[C@H](N(C1)C)C(=O)NC([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)C(C)Cl
InChI	1S/C18H33ClN2O5S.C18H34N2O6S/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4;1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25);9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9 ,10-,11+,12 ,13+,14-,15-,16-,18-;9-,10-,11+,12-,13+,14-,15-,16-,18-/m11/s1
InChIKey	MMYMXHAXTQPVRO-DGXIQQDPSA-N
PubChem CID	56842237

Type(s) of Resistant Mechanism of This Drug

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-01: Infectious/parasitic diseases

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Staphylococcus meningitis [ICD-11: 1B54]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)		Click to Show/Hide
Key Molecule: Erythromycin resistance protein (ERM33)			[1]
Molecule Alteration	Expression	Gene recombination	Molecule Info
Resistant Disease	Staphylococcus sciuri infection [ICD-11: 1B54.1]		Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Staphylococcus sciuri plasmid pSCFS1		1296
Experiment for Molecule Alteration	Sequence analysis
Experiment for Drug Resistance	MIC assay
Mechanism Description	Staphylococcus sciuri Gene erm(33), Encoding Inducible Resistance to Macrolides, Lincosamides, and Streptogramin B Antibiotics, Is a Product of Recombination between erm(C) and erm(A).

References

Ref 1	Staphylococcus sciuri gene erm(33), encoding inducible resistance to macrolides, lincosamides, and streptogramin B antibiotics, is a product of recombination between erm(C) and erm(A). Antimicrob Agents Chemother. 2002 Nov;46(11):3621-3. doi: 10.1128/AAC.46.11.3621-3623.2002.