Molecule Information

General Information of the Molecule (ID: Mol00869)

Name	Chloramphenicol acetyltransferase (CAT) ,Campylobacter coli
Synonyms	CAT Click to Show/Hide
Molecule Type	Protein
Gene Name	CAT
Sequence	MQFTKIDINNWTRKEYFDHYFGNTPCTYSMTVKLDISKLKKDGKKLYPTLLYGVTTIINR HEEFRTALDENGQVGVFSEMLPCYTVFHKETETFSSIWTEFTADYTEFLQNYQKDIDAFG ERMGMSAKPNPPENTFPVSMIPWTSFEGFNLNLKKGYDYLLPIFTFGKYYEEGGKYYIPL SIQVHHAVCDGFHVCRFLDELQDLLNK Click to Show/Hide
Function	This enzyme is an effector of chloramphenicol resistance in bacteria. Click to Show/Hide
Uniprot ID	CAT_CAMCO
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Proteobacteria Class: Epsilonproteobacteria Order: Campylobacterales Family: Campylobacteraceae Genus: Campylobacter Species: Campylobacter coli

Type(s) of Resistant Mechanism of This Molecule

DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Chloramphenicol

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Drug Inactivation by Structure Modification (DISM)		Click to Show/Hide
Disease Class: Campylobacter fetus infection			[1]
Resistant Disease	Campylobacter fetus infection [ICD-11: 1C40.0]		Disease Info
Resistant Drug	Chloramphenicol		Drug Info
Molecule Alteration	Expression	Inherence
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	Campylobacter coli strain UA585		195
	Escherichia coli strain JM 107		562
Mechanism Description	A chloramphenicol-resistance determinant (CmR), originally cloned from Campylobacter coli plasmid pNR9589 in Japan, was isolated and the nucleotide sequence determined, which contained an open reading frame of 621 bp. The gene product was identified as Cm acetyltransferase (CAT), which had a putative amino acid sequence that showed 43% to 57% identity with other CAT proteins of both Gram+ and Gram- origin.

References

Ref 1	Chloramphenicol resistance in Campylobacter coli: nucleotide sequence, expression, and cloning vector construction. Gene. 1990 Sep 28;94(1):23-8. doi: 10.1016/0378-1119(90)90463-2.