Molecule Information

General Information of the Molecule (ID: Mol00727)
Name
Dihydrofolate reductase/DNA-directed RNA polymerase subunit beta (DHFR/RPOB) ,Mycobacterium leprae
Molecule Type
Protein
Gene Name
DHFR/RPOB
Uniprot ID
DHPS1_MYCLE/RPOB_MYCLE
        Click to Show/Hide the Complete Species Lineage
Kingdom: N.A.
Phylum: Actinobacteria
Class: Actinomycetia
Order: Corynebacteriales
Family: Mycobacteriaceae
Genus: Mycobacterium
Species: Mycobacterium leprae
Type(s) of Resistant Mechanism of This Molecule
  ADTT: Aberration of the Drug's Therapeutic Target
Drug Resistance Data Categorized by Drug
Approved Drug(s)
4 drug(s) in total
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Clofazimine
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Disease Class: Leprosy [1]
Resistant Disease Leprosy [ICD-11: 1B20.0]
 Disease Info 
Resistant Drug Clofazimine
 Drug Info 
Molecule Alteration Missense mutation
folP p.P55L+poB p.S531L
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium leprae isolates 1769
In Vivo Model Footpad granuloma from M. leprae-infected nude mice model Mus musculus
Experiment for
Molecule Alteration		 PCR and single-stranded conformational polymorphism (SSCP) assay
Experiment for
Drug Resistance		 Mouse footpad assay
Mechanism Description The mutations genes reported in this study have been demonstrated to be responsible for drug resistance by mouse footpad assay.
Disease Class: Leprosy [1]
Resistant Disease Leprosy [ICD-11: 1B20.0]
 Disease Info 
Resistant Drug Clofazimine
 Drug Info 
Molecule Alteration Missense mutation
folP p.P55S+rpoB p.S531L+rpoB p.V547I
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium leprae isolates 1769
In Vivo Model Footpad granuloma from M. leprae-infected nude mice model Mus musculus
Experiment for
Molecule Alteration		 PCR and single-stranded conformational polymorphism (SSCP) assay
Experiment for
Drug Resistance		 Mouse footpad assay
Mechanism Description The mutations genes reported in this study have been demonstrated to be responsible for drug resistance by mouse footpad assay.
Dapsone
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Disease Class: Leprosy [1]
Resistant Disease Leprosy [ICD-11: 1B20.0]
 Disease Info 
Resistant Drug Dapsone
 Drug Info 
Molecule Alteration Missense mutation
folP p.P55L+poB p.S531L
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium leprae isolates 1769
In Vivo Model Footpad granuloma from M. leprae-infected nude mice model Mus musculus
Experiment for
Molecule Alteration		 PCR and single-stranded conformational polymorphism (SSCP) assay
Experiment for
Drug Resistance		 Mouse footpad assay
Mechanism Description The mutations genes reported in this study have been demonstrated to be responsible for drug resistance by mouse footpad assay.
Disease Class: Leprosy [1]
Resistant Disease Leprosy [ICD-11: 1B20.0]
 Disease Info 
Resistant Drug Dapsone
 Drug Info 
Molecule Alteration Missense mutation
folP p.P55S+rpoB p.S531L+rpoB p.V547I
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium leprae isolates 1769
In Vivo Model Footpad granuloma from M. leprae-infected nude mice model Mus musculus
Experiment for
Molecule Alteration		 PCR and single-stranded conformational polymorphism (SSCP) assay
Experiment for
Drug Resistance		 Mouse footpad assay
Mechanism Description The mutations genes reported in this study have been demonstrated to be responsible for drug resistance by mouse footpad assay.
Ofloxacin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Disease Class: Leprosy [1]
Resistant Disease Leprosy [ICD-11: 1B20.0]
 Disease Info 
Resistant Drug Ofloxacin
 Drug Info 
Molecule Alteration Missense mutation
folP p.P55L+poB p.S531L
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium leprae isolates 1769
In Vivo Model Footpad granuloma from M. leprae-infected nude mice model Mus musculus
Experiment for
Molecule Alteration		 PCR and single-stranded conformational polymorphism (SSCP) assay
Experiment for
Drug Resistance		 Mouse footpad assay
Mechanism Description The mutations genes reported in this study have been demonstrated to be responsible for drug resistance by mouse footpad assay.
Disease Class: Leprosy [1]
Resistant Disease Leprosy [ICD-11: 1B20.0]
 Disease Info 
Resistant Drug Ofloxacin
 Drug Info 
Molecule Alteration Missense mutation
folP p.P55S+rpoB p.S531L+rpoB p.V547I
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium leprae isolates 1769
In Vivo Model Footpad granuloma from M. leprae-infected nude mice model Mus musculus
Experiment for
Molecule Alteration		 PCR and single-stranded conformational polymorphism (SSCP) assay
Experiment for
Drug Resistance		 Mouse footpad assay
Mechanism Description The mutations genes reported in this study have been demonstrated to be responsible for drug resistance by mouse footpad assay.
Rifampin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Disease Class: Leprosy [1]
Resistant Disease Leprosy [ICD-11: 1B20.0]
 Disease Info 
Resistant Drug Rifampin
 Drug Info 
Molecule Alteration Missense mutation
folP p.P55L+poB p.S531L
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium leprae isolates 1769
In Vivo Model Footpad granuloma from M. leprae-infected nude mice model Mus musculus
Experiment for
Molecule Alteration		 PCR and single-stranded conformational polymorphism (SSCP) assay
Experiment for
Drug Resistance		 Mouse footpad assay
Mechanism Description The mutations genes reported in this study have been demonstrated to be responsible for drug resistance by mouse footpad assay.
Disease Class: Leprosy [1]
Resistant Disease Leprosy [ICD-11: 1B20.0]
 Disease Info 
Resistant Drug Rifampin
 Drug Info 
Molecule Alteration Missense mutation
folP p.P55S+rpoB p.S531L+rpoB p.V547I
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium leprae isolates 1769
In Vivo Model Footpad granuloma from M. leprae-infected nude mice model Mus musculus
Experiment for
Molecule Alteration		 PCR and single-stranded conformational polymorphism (SSCP) assay
Experiment for
Drug Resistance		 Mouse footpad assay
Mechanism Description The mutations genes reported in this study have been demonstrated to be responsible for drug resistance by mouse footpad assay.
References
Ref 1 Mutations in genes related to drug resistance in Mycobacterium leprae isolates from leprosy patients in Korea. J Infect. 2005 Jan;50(1):6-11. doi: 10.1016/j.jinf.2004.03.012.

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