Drug Information

Drug (ID: DG01844) and It's Reported Resistant Information

• Name: 5-FU-CDDP
• Synonyms: 5-FU-CDDP protocol; 5-FU-CDDP regimen; 5-FU-CDDP; SCHEMBL5916102; Cisplatin regimen with Fluorouracil; C112530000
• Drug Resistance Disease(s):
  Disease(s) with Clinically Reported Resistance for This Drug (2 diseases)
  Liver cancer [ICD-11: 2C12]; [1]
  Mature T-cell lymphoma [ICD-11: 2A90]; [2]
  Disease(s) with Resistance Information Discovered by Cell Line Test for This Drug (1 diseases)
  Lung cancer [ICD-11: 2C25]; [3]
• Target: .; NOUNIPROTAC; [1]
• IsoSMILES: C1=C(C(=O)NC(=O)N1)F.[NH2-].[NH2-].Cl[Pt+2]Cl
• InChI: InChI=1S/C4H3FN2O2.2ClH.2H2N.Pt/c5-2-1-6-4(9)7-3(2)8;;;;;/h1H,(H2,6,7,8,9);2*1H;2*1H2;/q;;;2*-1;+4/p-2
• InChIKey: LVOCGPWBRTUSAU-UHFFFAOYSA-L
• PubChem CID: 56842080

Type(s) of Resistant Mechanism of This Drug

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Mature T-cell lymphoma [ICD-11: 2A90]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Small nucleolar RNA host gene 12 (SNHG12) [2]

• Molecule Alteration: Up-regulation; Interaction
• Resistant Disease: Natural killer/T-cell lymphoma [ICD-11: 2A90.2]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: SNK-6 cells; Oral; Homo sapiens (Human); CVCL_A673
• In Vitro Model: YTS cells; Pleural effusion; Homo sapiens (Human); CVCL_D324
• In Vitro Model: SNK-1; Peripheral blood; Homo sapiens (Human); CVCL_A671
• In Vitro Model: SNT-8 cells; Blood; Homo sapiens (Human); CVCL_A677
• Experiment for Molecule Alteration: Overexpression assay
• Experiment for Drug Resistance: MTT assay
• Mechanism Description: c-Myc mediated upregulation of long noncoding RNA SNHG12 regulates proliferation and drug sensitivity in natural killer/T-cell lymphoma.

Liver cancer [ICD-11: 2C12]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Maternally expressed 3 (MEG3) [1]

• Molecule Alteration: Up-regulation; Interaction
• Resistant Disease: Cholangiocarcinoma [ICD-11: 2C12.0]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: HepG2 cells; Liver; Homo sapiens (Human); CVCL_0027
• In Vitro Model: HCC Huh7 cells; Liver; Homo sapiens (Human); CVCL_0336
• In Vitro Model: 7721 cells; N.A.; Homo sapiens (Human); N.A.
• In Vitro Model: 7402 cells; Uterus; Homo sapiens (Human); CVCL_5492
• In Vitro Model: LO2 cells; Uterus; Homo sapiens (Human); CVCL_6926
• Experiment for Molecule Alteration: Overexpression assay
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: MEG3 overexpression inhibited the proliferation of HCC cells, at least in part by affecting miR-664mediated regulation of ADH4.

Lung cancer [ICD-11: 2C25]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Nuclear paraspeckle assembly transcript 1 (NEAT1) [3]

• Molecule Alteration: Up-regulation; Expression
• Resistant Disease: Lung adenocarcinoma [ICD-11: 2C25.0]
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: A549 cells; Lung; Homo sapiens (Human); CVCL_0023
• Experiment for Molecule Alteration: Overexpression assay; Knockdown assay
• Experiment for Drug Resistance: MTT assay
• Mechanism Description: NEAT1 contributes to the CSC-like traits of A549/CDDP cells via activating Wnt signaling pathway.

References

• Ref 1: LncRNA MEG3 contributes to adenosine-induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K-AKT-mTOR and beclin-1 signaling pathwayJ Cell Biochem. 2019 Oct;120(10):18172-18185. doi: 10.1002/jcb.29123. Epub 2019 May 29.
• Ref 2: c-Myc mediated upregulation of long noncoding RNA SNHG12 regulates proliferation and drug sensitivity in natural killer/T-cell lymphomaJ Cell Biochem. 2019 Aug;120(8):12628-12637. doi: 10.1002/jcb.28529. Epub 2019 Mar 1.
• Ref 3: NEAT1 regulates MPP(+)-induced neuronal injury by targeting miR-124 in neuroblastoma cellsNeurosci Lett. 2019 Aug 24;708:134340. doi: 10.1016/j.neulet.2019.134340. Epub 2019 Jun 19.