Molecule Information

General Information of the Molecule (ID: Mol01227)

• Name: Small nucleolar RNA host gene 12 (SNHG12) ,Homo sapiens
• Synonyms: SNHG12
• Molecule Type: LncRNA
• Gene Name: GLYT1
• Gene ID: 85028
• Location: chr1:28578538-28583132[-]
• Ensembl ID: ENSG00000197989
• HGNC ID: HGNC:30062

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Doxorubicin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Osteosarcoma [1]

• Resistant Disease: Osteosarcoma [ICD-11: 2B51.0]
• Resistant Drug: Doxorubicin
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Identified from the Human Clinical Data
• Cell Pathway Regulation: Cell apoptosis; Inhibition; hsa04210
• Cell Pathway Regulation: Cell viability; Activation; hsa05200
• In Vitro Model: MG63 cells; Bone marrow; Homo sapiens (Human); CVCL_0426
• In Vitro Model: SAOS-2 cells; Bone marrow; Homo sapiens (Human); CVCL_0548
• In Vitro Model: U2OS cells; Bone; Homo sapiens (Human); CVCL_0042
• In Vitro Model: HOS cells; Bone; Homo sapiens (Human); CVCL_0312
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: CCK8 assay; Flow cytometry assay
• Mechanism Description: The up-regulation of MCL1 reversed the sensitivity of doxorubicin induced by miR-320a mimics and knockdown of SNHG12.

Investigative Drug(s) 1 drug(s) in total

5-FU-CDDP

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Natural killer/T-cell lymphoma [2]

• Resistant Disease: Natural killer/T-cell lymphoma [ICD-11: 2A90.2]
• Resistant Drug: 5-FU-CDDP
• Molecule Alteration: Up-regulation; Interaction
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: SNK-6 cells; Oral; Homo sapiens (Human); CVCL_A673
• In Vitro Model: YTS cells; Pleural effusion; Homo sapiens (Human); CVCL_D324
• In Vitro Model: SNK-1; Peripheral blood; Homo sapiens (Human); CVCL_A671
• In Vitro Model: SNT-8 cells; Blood; Homo sapiens (Human); CVCL_A677
• Experiment for Molecule Alteration: Overexpression assay
• Experiment for Drug Resistance: MTT assay
• Mechanism Description: c-Myc mediated upregulation of long noncoding RNA SNHG12 regulates proliferation and drug sensitivity in natural killer/T-cell lymphoma.

References

• Ref 1: Long noncoding RNA SNHG12 mediates doxorubicin resistance of osteosarcoma via miR-320a/MCL1 axis. Biomed Pharmacother. 2018 Oct;106:850-857. doi: 10.1016/j.biopha.2018.07.003. Epub 2018 Jul 11.
• Ref 2: c-Myc mediated upregulation of long noncoding RNA SNHG12 regulates proliferation and drug sensitivity in natural killer/T-cell lymphomaJ Cell Biochem. 2019 Aug;120(8):12628-12637. doi: 10.1002/jcb.28529. Epub 2019 Mar 1.