Drug Information

Drug (ID: DG01808) and It's Reported Resistant Information

Name	Heliox
Synonyms	Heliox; helium;molecular oxygen; 58933-55-4; Helium, mixed with oxygen; Helium-oxygen mixture; Helium:oxygen mixture; Compressed gas, N.O.S.; Oxygen mixture with helium; Oxygen, mixed with helium; Heliox gas; Helium oxygen gas; Heliox, hyperbaric; Helium, mixt. with oxygen; Compressed gas, N.O.S. (helium, oxygen) gas; 70356-00-2 Click to Show/Hide
Structure
Drug Resistance Disease(s)	Disease(s) with Resistance Information Discovered by Cell Line Test for This Drug (1 diseases) Ischemic cardiovascular disease [ICD-11: BA51] [1]
Target	.	NOUNIPROTAC	[1]
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IsoSMILES	[He].O=O
InChI	InChI=1S/He.O2/c;1-2
InChIKey	GWUAFYNDGVNXRS-UHFFFAOYSA-N
PubChem CID	123812

Type(s) of Resistant Mechanism of This Drug

RTDM: Regulation by the Disease Microenvironment

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-11: Circulatory system diseases

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Ischemic cardiovascular disease [ICD-11: BA51]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Regulation by the Disease Microenvironment (RTDM)			Click to Show/Hide
Key Molecule: Metastasis associated lung adenocarcinoma transcript 1 (MALAT1)				[1]
Molecule Alteration	Up-regulation		Interaction	Molecule Info
Resistant Disease	Ischemic cardiovascular disease [ICD-11: BA51.0]			Disease Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HCAECs	N.A.	.	N.A.
In Vivo Model	Hind limb ischemia rat model			Rattus norvegicus
Experiment for Molecule Alteration	Overexpression assay; Knockdown assay; Luciferase assay
Experiment for Drug Resistance	CellTiter-Glo assay; dual-luciferase reporter assay
Mechanism Description	Hyperbaric oxygen boosts long noncoding RNA MALAT1 exosome secretion to suppress microRNA-92a expression in therapeutic angiogenesis.

References

Ref 1	Long non-coding RNA MALAT1 interacts with transcription factor Foxo1 to regulate SIRT1 transcription in high glucose-induced HK-2 cells injuryBiochem Biophys Res Commun. 2018 Sep 5;503(2):849-855. doi: 10.1016/j.bbrc.2018.06.086. Epub 2018 Jul 14.