General Information of the Disease (ID: DIS00398)
Name
Ischemic cardiovascular disease
ICD
ICD-11: BA51
Resistance Map
Type(s) of Resistant Mechanism of This Disease
  RTDM: Regulation by the Disease Microenvironment
Drug Resistance Data Categorized by Drug
Investigative Drug(s)
1 drug(s) in total
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Heliox
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Regulation by the Disease Microenvironment (RTDM) Click to Show/Hide
Key Molecule: Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) [1]
Resistant Disease Ischemic cardiovascular disease [ICD-11: BA51.0]
Molecule Alteration Up-regulation
Interaction
Resistant Drug Heliox
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model HCAECs N.A. . N.A.
In Vivo Model Hind limb ischemia rat model Rattus norvegicus
Experiment for
Molecule Alteration
Overexpression assay; Knockdown assay; Luciferase assay
Experiment for
Drug Resistance
CellTiter-Glo assay; dual-luciferase reporter assay
Mechanism Description Hyperbaric oxygen boosts long noncoding RNA MALAT1 exosome secretion to suppress microRNA-92a expression in therapeutic angiogenesis.
References
Ref 1 Long non-coding RNA MALAT1 interacts with transcription factor Foxo1 to regulate SIRT1 transcription in high glucose-induced HK-2 cells injuryBiochem Biophys Res Commun. 2018 Sep 5;503(2):849-855. doi: 10.1016/j.bbrc.2018.06.086. Epub 2018 Jul 14.

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