Disease Information
General Information of the Disease (ID: DIS00398)
Name |
Ischemic cardiovascular disease
|
---|---|
ICD |
ICD-11: BA51
|
Resistance Map |
Type(s) of Resistant Mechanism of This Disease
RTDM: Regulation by the Disease Microenvironment
Drug Resistance Data Categorized by Drug
Investigative Drug(s)
1 drug(s) in total
Heliox
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Regulation by the Disease Microenvironment (RTDM) | ||||
Key Molecule: Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | [1] | |||
Resistant Disease | Ischemic cardiovascular disease [ICD-11: BA51.0] | |||
Molecule Alteration | Up-regulation | Interaction |
||
Resistant Drug | Heliox | |||
Experimental Note | Revealed Based on the Cell Line Data | |||
In Vitro Model | HCAECs | N.A. | . | N.A. |
In Vivo Model | Hind limb ischemia rat model | Rattus norvegicus | ||
Experiment for Molecule Alteration |
Overexpression assay; Knockdown assay; Luciferase assay | |||
Experiment for Drug Resistance |
CellTiter-Glo assay; dual-luciferase reporter assay | |||
Mechanism Description | Hyperbaric oxygen boosts long noncoding RNA MALAT1 exosome secretion to suppress microRNA-92a expression in therapeutic angiogenesis. |
References
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