Drug Information

Drug (ID: DG00571) and It's Reported Resistant Information
Name
Intravenous immunoglobulin
Indication
In total 1 Indication(s)
Primary Immunodeficiency [ICD-11: 4A01]
Approved
[1]
Drug Resistance Disease(s)
Disease(s) with Clinically Reported Resistance for This Drug (1 diseases)
Kawasaki disease [ICD-11: 4A44]
[1]
Target . NOUNIPROTAC [1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
DrugBank ID
DB00028
Type(s) of Resistant Mechanism of This Drug
  IDUE: Irregularity in Drug Uptake and Drug Efflux
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-04: Immune system diseases
Click to Show/Hide the Resistance Disease of This Class
Kawasaki disease [ICD-11: 4A44]
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: ATP-binding cassette sub-family C4 (ABCC4) [1]
Molecule Alteration SNP
rs1751034
 Molecule Info 
Resistant Disease Kawasaki disease [ICD-11: 4A44.5]
 Disease Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Blood sample N.A.
Experiment for
Molecule Alteration		 qRT-PCR
Mechanism Description Patients with 3-6 risk genotypes had significantly higher risk of IVIG resistance in KD than those with 0-2 risk genotypes, especially in children aged less than or equal to months and males. This is the first study in which MRP4 gene SNPs were found to be associated with IVIG resistance in KD.
Key Molecule: ATP-binding cassette sub-family C4 (ABCC4) [1]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Resistant Disease Kawasaki disease [ICD-11: 4A44.5]
 Disease Info 
Experimental Note Identified from the Human Clinical Data
Mechanism Description The homozygous of MRP4 gene rs1751034 C allele is significantly associated with IVIG resistance in KD, especially in patients younger than 5 years old and boys.
Key Molecule: ATP-binding cassette sub-family C4 (ABCC4) [1]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Resistant Disease Kawasaki disease [ICD-11: 4A44.5]
 Disease Info 
Experimental Note Identified from the Human Clinical Data
Mechanism Description The homozygous of MRP4 gene rs1751034 C allele is significantly associated with IVIG resistance in KD, especially in patients younger than 5 years old and boys.
References
Ref 1 Homozygous of MRP4 Gene rs1751034 C Allele Is Related to Increased Risk of Intravenous Immunoglobulin Resistance in Kawasaki Disease .Front Genet. 2021 Mar 15;12:510350. doi: 10.3389/fgene.2021.510350. eCollection 2021. 10.3389/fgene.2021.510350

If you find any error in data or bug in web service, please kindly report it to Dr. Sun and Dr. Zhang.