Disease Information

General Information of the Disease (ID: DIS00232)

• Name: Kawasaki disease
• ICD: ICD-11: 4A44

Type(s) of Resistant Mechanism of This Disease

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Intravenous immunoglobulin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Key Molecule: ATP-binding cassette sub-family C4 (ABCC4) [1]

• Resistant Disease: Kawasaki disease [ICD-11: 4A44.5]
• Molecule Alteration: SNP; rs1751034
• Resistant Drug: Intravenous immunoglobulin
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Blood sample; .
• Experiment for Molecule Alteration: qRT-PCR
• Mechanism Description: Patients with 3-6 risk genotypes had significantly higher risk of IVIG resistance in KD than those with 0-2 risk genotypes, especially in children aged less than or equal to months and males. This is the first study in which MRP4 gene SNPs were found to be associated with IVIG resistance in KD.

Key Molecule: ATP-binding cassette sub-family C4 (ABCC4) [1]

• Resistant Disease: Kawasaki disease [ICD-11: 4A44.5]
• Molecule Alteration: Expression; Up-regulation
• Resistant Drug: Intravenous immunoglobulin
• Experimental Note: Identified from the Human Clinical Data
• Mechanism Description: The homozygous of MRP4 gene rs1751034 C allele is significantly associated with IVIG resistance in KD, especially in patients younger than 5 years old and boys.

Key Molecule: ATP-binding cassette sub-family C4 (ABCC4) [1]

• Resistant Disease: Kawasaki disease [ICD-11: 4A44.5]
• Molecule Alteration: Expression; Up-regulation
• Resistant Drug: Intravenous immunoglobulin
• Experimental Note: Identified from the Human Clinical Data
• Mechanism Description: The homozygous of MRP4 gene rs1751034 C allele is significantly associated with IVIG resistance in KD, especially in patients younger than 5 years old and boys.

References

• Ref 1: Homozygous of MRP4 Gene rs1751034 C Allele Is Related to Increased Risk of Intravenous Immunoglobulin Resistance in Kawasaki Disease .Front Genet. 2021 Mar 15;12:510350. doi: 10.3389/fgene.2021.510350. eCollection 2021. 10.3389/fgene.2021.510350