Drug Information

Drug (ID: DG00493) and It's Reported Resistant Information

Name	Moenomycin A
Drug Resistance Disease(s)	Disease(s) with Clinically Reported Resistance for This Drug (2 diseases) Bacteremia [ICD-11: MA15] [1], [2], [3] Bacterial infection [ICD-11: 1A00-1C4Z] [1], [2], [3]

Type(s) of Resistant Mechanism of This Drug

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-01: Infectious/parasitic diseases

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Bacterial infection [ICD-11: 1A00-1C4Z]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: ATP-binding cassette transporter A (ABCA)			[1], [2], [3]
Molecule Alteration	Expression	Up-regulation	Molecule Info
Resistant Disease	Bacterial infection [ICD-11: 1A00-1C4Z]		Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli TOP10		83333
	Staphylococcus aureus MW2		1242971
In Vivo Model	Swiss webster male mice model		Mus musculus
Experiment for Molecule Alteration	Whole genome sequence assay
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	The ATP-dependent transporter gene abcA in Staphylococcus aureus confers resistance to hydrophobic Beta-lactams.

ICD-21: Symptoms/clinical signs/unclassified clinical findings

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Bacteremia [ICD-11: MA15]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: ATP-binding cassette transporter A (ABCA)			[1], [2], [3]
Molecule Alteration	Expression	Up-regulation	Molecule Info
Resistant Disease	Bacteremia [ICD-11: MA15.0]		Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli TOP10		83333
	Staphylococcus aureus MW2		1242971
In Vivo Model	Swiss webster male mice model		Mus musculus
Experiment for Molecule Alteration	Whole genome sequence assay
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	The ATP-dependent transporter gene abcA in Staphylococcus aureus confers resistance to hydrophobic Beta-lactams.

References

Ref 1	Regulation of antibiotic resistance in Staphylococcus aureus. Int J Med Microbiol. 2010 Feb;300(2-3):118-29. doi: 10.1016/j.ijmm.2009.08.015. Epub 2009 Oct 2.
Ref 2	Regulation of expression of abcA and its response to environmental conditions. J Bacteriol. 2014 Apr;196(8):1532-9. doi: 10.1128/JB.01406-13. Epub 2014 Feb 7.
Ref 3	Multidrug-Resistance Transporter AbcA Secretes Staphylococcus aureus Cytolytic Toxins. J Infect Dis. 2016 Jan 15;213(2):295-304. doi: 10.1093/infdis/jiv376. Epub 2015 Jul 9.