Drug Information

Drug (ID: DG00484) and It's Reported Resistant Information

• Name: Elfamycin
• Indication:
  In total 1 Indication(s)
  Infectious gastroenteritis/colitis [ICD-11: 1A40]; Investigative; [1]
• Drug Resistance Disease(s):
  Disease(s) with Clinically Reported Resistance for This Drug (2 diseases)
  Bacterial infection [ICD-11: 1A00-1C4Z]; [1]
  COVID-19 [ICD-11: 1D92]; [2]
• TTD Drug ID: D0U4IV

Type(s) of Resistant Mechanism of This Drug

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-01: Infectious/parasitic diseases

Bacterial infection [ICD-11: 1A00-1C4Z]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Key Molecule: Elongation factor Tu (TUF) [1]

• Molecule Alteration: Expression; Inherence
• Resistant Disease: Enterococci faecalis infection [ICD-11: 1A00-1C4Z]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Enterococcus avium strain NCTC9938; 33945
• In Vitro Model: Enterococcus casseliflavus strain NCIMB11449; 37734
• In Vitro Model: Enterococcus durans strain NCTC8174; 53345
• In Vitro Model: Enterococcus faecalis strain NCTC775; 1351
• In Vitro Model: Enterococcus faecium strain NCTC 7171; 1352
• In Vitro Model: Enterococcus gallinarum strain NCTC11428; 1353
• In Vitro Model: Enterococcus hirae strain NCIMB6459; 1354
• In Vitro Model: Enterococcus raffinosus strain NCTC 12192; 1989
• Experiment for Drug Resistance: Agar dilution assay
• Mechanism Description: Among enterococci, susceptibility or resistance to elfamycins appears to be determined by the bacterial protein synthesis elongation factor EF-Tu. E.faecium, E.durans, and E.hirae were susceptible to the elfamycins, while isolates of E.faecalis and all other species tested were resistant. Elfamycin resistance in E.faecalis ATCC7080 was mediated by the intrinsic resistance of its EF-Tu.

Key Molecule: Elongation factor Tu (TUF) [1]

• Molecule Alteration: Expression; Inherence
• Resistant Disease: Enterococci casseliflavus infection [ICD-11: 1A00-1C4Z]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Enterococcus avium strain NCTC9938; 33945
• In Vitro Model: Enterococcus casseliflavus strain NCIMB11449; 37734
• In Vitro Model: Enterococcus durans strain NCTC8174; 53345
• In Vitro Model: Enterococcus faecalis strain NCTC775; 1351
• In Vitro Model: Enterococcus faecium strain NCTC 7171; 1352
• In Vitro Model: Enterococcus gallinarum strain NCTC11428; 1353
• In Vitro Model: Enterococcus hirae strain NCIMB6459; 1354
• In Vitro Model: Enterococcus raffinosus strain NCTC 12192; 1989
• Experiment for Drug Resistance: Agar dilution assay
• Mechanism Description: Among enterococci, susceptibility or resistance to elfamycins appears to be determined by the bacterial protein synthesis elongation factor EF-Tu. E.faecium, E.durans, and E.hirae were susceptible to the elfamycins, while isolates of E.faecalis and all other species tested were resistant. Elfamycin resistance in E.faecalis ATCC7080 was mediated by the intrinsic resistance of its EF-Tu.

Key Molecule: Elongation factor Tu (TUF) [1]

• Molecule Alteration: Expression; Inherence
• Resistant Disease: Enterococci avium infection [ICD-11: 1A00-1C4Z]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Enterococcus avium strain NCTC9938; 33945
• In Vitro Model: Enterococcus casseliflavus strain NCIMB11449; 37734
• In Vitro Model: Enterococcus durans strain NCTC8174; 53345
• In Vitro Model: Enterococcus faecalis strain NCTC775; 1351
• In Vitro Model: Enterococcus faecium strain NCTC 7171; 1352
• In Vitro Model: Enterococcus gallinarum strain NCTC11428; 1353
• In Vitro Model: Enterococcus hirae strain NCIMB6459; 1354
• In Vitro Model: Enterococcus raffinosus strain NCTC 12192; 1989
• Experiment for Drug Resistance: Agar dilution assay
• Mechanism Description: Among enterococci, susceptibility or resistance to elfamycins appears to be determined by the bacterial protein synthesis elongation factor EF-Tu. E.faecium, E.durans, and E.hirae were susceptible to the elfamycins, while isolates of E.faecalis and all other species tested were resistant. Elfamycin resistance in E.faecalis ATCC7080 was mediated by the intrinsic resistance of its EF-Tu.

Key Molecule: Elongation factor Tu (TUF) [1]

• Molecule Alteration: Expression; Inherence
• Resistant Disease: Enterococci raffinosus infection [ICD-11: 1A00-1C4Z]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Enterococcus avium strain NCTC9938; 33945
• In Vitro Model: Enterococcus casseliflavus strain NCIMB11449; 37734
• In Vitro Model: Enterococcus durans strain NCTC8174; 53345
• In Vitro Model: Enterococcus faecalis strain NCTC775; 1351
• In Vitro Model: Enterococcus faecium strain NCTC 7171; 1352
• In Vitro Model: Enterococcus gallinarum strain NCTC11428; 1353
• In Vitro Model: Enterococcus hirae strain NCIMB6459; 1354
• In Vitro Model: Enterococcus raffinosus strain NCTC 12192; 1989
• Experiment for Drug Resistance: Agar dilution assay
• Mechanism Description: Among enterococci, susceptibility or resistance to elfamycins appears to be determined by the bacterial protein synthesis elongation factor EF-Tu. E.faecium, E.durans, and E.hirae were susceptible to the elfamycins, while isolates of E.faecalis and all other species tested were resistant. Elfamycin resistance in E.faecalis ATCC7080 was mediated by the intrinsic resistance of its EF-Tu.

Key Molecule: Elongation factor Tu (TUF) [1]

• Molecule Alteration: Expression; Inherence
• Resistant Disease: Enterococci gallinarum infection [ICD-11: 1A00-1C4Z]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Enterococcus avium strain NCTC9938; 33945
• In Vitro Model: Enterococcus casseliflavus strain NCIMB11449; 37734
• In Vitro Model: Enterococcus durans strain NCTC8174; 53345
• In Vitro Model: Enterococcus faecalis strain NCTC775; 1351
• In Vitro Model: Enterococcus faecium strain NCTC 7171; 1352
• In Vitro Model: Enterococcus gallinarum strain NCTC11428; 1353
• In Vitro Model: Enterococcus hirae strain NCIMB6459; 1354
• In Vitro Model: Enterococcus raffinosus strain NCTC 12192; 1989
• Experiment for Drug Resistance: Agar dilution assay
• Mechanism Description: Among enterococci, susceptibility or resistance to elfamycins appears to be determined by the bacterial protein synthesis elongation factor EF-Tu. E.faecium, E.durans, and E.hirae were susceptible to the elfamycins, while isolates of E.faecalis and all other species tested were resistant. Elfamycin resistance in E.faecalis ATCC7080 was mediated by the intrinsic resistance of its EF-Tu.

References

• Ref 1: Differential susceptibilities of enterococcal species to elfamycin antibiotics. J Clin Microbiol. 1994 Aug;32(8):2016-8. doi: 10.1128/jcm.32.8.2016-2018.1994.
• Ref 2: Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7 Nature. 2021 May;593(7857):130-135. doi: 10.1038/s41586-021-03398-2. Epub 2021 Mar 8.