General Information of the Molecule (ID: Mol00947)
Name
Elongation factor Tu (TUF) ,Enterococcus gallinarum
Synonyms
tufB; Fragment
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Molecule Type
Protein
Gene Name
tufB
Sequence
GAILVVSATDGPMPQTREHILLSRQVGVKHLIVFLNKIDLVDDEELIDLVEMEVRELLSE
YNFPGDDIPVIKGSALKALEGDPDAEAAIMELMDTVDSYIPTPERDTDKPLLLPVEDVFS
ITGRGTVASGRIDRGTVRVGDEVEIVGIKPETQKAVVTGVEMFRKTMDFGEAGDNVGVLL
RGITRDEIERGQVLAKPGSITPHTKFQAEVYVLTKEEGGRHTPFFNNYRPQFYFRTTDVT
GNITLPEGTE
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Uniprot ID
Q9EZY1_ENTGA
        Click to Show/Hide the Complete Species Lineage
Kingdom: N.A.
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus gallinarum
Type(s) of Resistant Mechanism of This Molecule
  ADTT: Aberration of the Drug's Therapeutic Target
Drug Resistance Data Categorized by Drug
Investigative Drug(s)
1 drug(s) in total
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Elfamycin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Disease Class: Enterococci gallinarum infection [1]
Resistant Disease Enterococci gallinarum infection [ICD-11: 1A00-1C4Z]
Resistant Drug Elfamycin
Molecule Alteration Expression
Inherence
Experimental Note Identified from the Human Clinical Data
In Vitro Model Enterococcus avium strain NCTC9938 33945
Enterococcus casseliflavus strain NCIMB11449 37734
Enterococcus durans strain NCTC8174 53345
Enterococcus faecalis strain NCTC775 1351
Enterococcus faecium strain NCTC 7171 1352
Enterococcus gallinarum strain NCTC11428 1353
Enterococcus hirae strain NCIMB6459 1354
Enterococcus raffinosus strain NCTC 12192 1989
Experiment for
Drug Resistance
Agar dilution assay
Mechanism Description Among enterococci, susceptibility or resistance to elfamycins appears to be determined by the bacterial protein synthesis elongation factor EF-Tu. E.faecium, E.durans, and E.hirae were susceptible to the elfamycins, while isolates of E.faecalis and all other species tested were resistant. Elfamycin resistance in E.faecalis ATCC7080 was mediated by the intrinsic resistance of its EF-Tu.
References
Ref 1 Differential susceptibilities of enterococcal species to elfamycin antibiotics. J Clin Microbiol. 1994 Aug;32(8):2016-8. doi: 10.1128/jcm.32.8.2016-2018.1994.

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