Drug Information

Drug (ID: DG00437) and It's Reported Resistant Information

• Name: Tetraphenylphosphonium bromide
• Synonyms: Tetraphenylphosphonium bromide; 2751-90-8; Phosphonium, tetraphenyl-, bromide; Phosphonium, tetraphenyl-, bromide (1:1); tetraphenylphosphanium;bromide; MFCD00011915; Tetraphenylphosponium bromide; Tetraphenylphosphoniumbromide; tetraphenylphosphanium,bromide; EINECS 220-393-4; Ph4PBr; Bromotetraphenylphosphorane; C24H20BrP; Tetraphenylphosphorus bromide; SCHEMBL42616; CHEMBL456063; DTXSID30883722; BCP24497; Tetraphenylphosphonium bromide, 97%; NSC115672; TETRAPHENYL-PHOSPHONIUM-BROMIDE; AKOS015833052; AKOS025117489; CS-W013858; NSC 115672; NSC-115672; AS-12560; DB-047239; FT-0634467; T1069; A819099; W-107108; Tetraphenylphosphonium bromide, Vetec(TM) reagent grade, 97%
• Drug Resistance Disease(s):
  Disease(s) with Clinically Reported Resistance for This Drug (1 diseases)
  Salmonellosis [ICD-11: 1A09]; [1]
• Formula: C24H20BrP
• IsoSMILES: C1=CC=C(C=C1)[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.[Br-]
• InChI: 1S/C24H20P.BrH/c1-5-13-21(14-6-1)25(22-15-7-2-8-16-22,23-17-9-3-10-18-23)24-19-11-4-12-20-24;/h1-20H;1H/q+1;/p-1
• InChIKey: BRKFQVAOMSWFDU-UHFFFAOYSA-M
• PubChem CID: 2724163

Type(s) of Resistant Mechanism of This Drug

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-01: Infectious/parasitic diseases

Salmonellosis [ICD-11: 1A09]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Key Molecule: Efflux pump membrane transporter MdsA (MDSA) [1]

• Molecule Alteration: Expression; Up-regulation
• Resistant Disease: Salmonella enterica infection [ICD-11: 1A09.0]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Salmonella enterica serovar Typhimurium ATCC 14028s; 588858
• Experiment for Molecule Alteration: Quantitative real-time PCR
• Experiment for Drug Resistance: L agar plate method assay
• Mechanism Description: Overexpression or overproduction of MdsABC confers drug resistance.

Key Molecule: Efflux pump membrane transporter MdsB (MDSB) [1]

• Molecule Alteration: Expression; Up-regulation
• Resistant Disease: Salmonella enterica infection [ICD-11: 1A09.0]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Salmonella enterica serovar Typhimurium ATCC 14028s; 588858
• Experiment for Molecule Alteration: Quantitative real-time PCR
• Experiment for Drug Resistance: L agar plate method assay
• Mechanism Description: Overexpression or overproduction of MdsABC confers drug resistance.

Key Molecule: Efflux pump membrane transporter MdsC (MDSC) [1]

• Molecule Alteration: Expression; Up-regulation
• Resistant Disease: Salmonella enterica infection [ICD-11: 1A09.0]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Salmonella enterica serovar Typhimurium ATCC 14028s; 588858
• Experiment for Molecule Alteration: Quantitative real-time PCR
• Experiment for Drug Resistance: L agar plate method assay
• Mechanism Description: Overexpression or overproduction of MdsABC confers drug resistance.

References

• Ref 1: Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium. Mol Microbiol. 2006 Jan;59(1):126-41. doi: 10.1111/j.1365-2958.2005.04940.x.