Drug Information

Drug (ID: DG00417) and It's Reported Resistant Information

• Name: Benzalkonium bromide
• Synonyms: Benzyldodecyldimethylammonium bromide; 7281-04-1; Benzalkonium bromide; Benzododecinium bromide; Sterinol; N-Benzyl-N,N-dimethyldodecan-1-aminium bromide; Bacfor BL; Benzyldimethyldodecylammonium bromide; Sinnoquat BL 95; 8043-47-8; Benzenemethanaminium, N-dodecyl-N,N-dimethyl-, bromide; benzyl-dodecyl-dimethylazanium;bromide; Dodecyl dimethyl benzyl ammonium bromide; N-Dodecyl-N,N-dimethylbenzenemethanaminium bromide; Dimethyl laurylbenzene ammonium bromide; UNII-IRY12B2TQ6; IRY12B2TQ6; Ajatin; MFCD00011768; DSSTox_CID_28624; DSSTox_RID_82894; DSSTox_GSID_48698; Lauralkonium bromide; Sinnoquat BL 80; Benzenemethanaminium, N-dodecyl-N,N-dimethyl-, bromide (1:1); CAS-7281-04-1; Ammonyl BR 1244; Benzododecinium bromatum; Caswell No. 416B; NCGC00164245-02; EINECS 230-698-4; EPA Pesticide Chemical Code 069123; Ammonium, benzyldodecyldimethyl-, bromide; Bromek dwumetylolaurylobenzyloamoniowy [Polish]; Benzalkonium bromide (C12); SCHEMBL119589; CHEMBL2355417; DTXSID4048698; CHEBI:167207; dimethyldodecylbenzylammonium bromide; Tox21_113091; benzyl-dodecyldimethylammonium bromide; Bromek dwumetylolaurylobenzyloamoniowy; AKOS015891185; Tox21_113091_1; NCGC00164245-03; BS-44064; I017; DB-056433; B3748; BENZYL(DODECYL)DIMETHYLAZANIUM BROMIDE; FT-0733931; D87631; N-Benzyl-N,N-dimethyldodecan-1-amonium bromide; N-Benzyl-N,N-dimethyldodecan-1-ammonium bromide; Q-200699; Q4890794; Benzalkonium bromide Dimethyl benzyl lauryl ammonium bromide; UNII-151T1GQ42D component KHSLHYAUZSPBIU-UHFFFAOYSA-M
• Drug Resistance Disease(s):
  Disease(s) with Clinically Reported Resistance for This Drug (1 diseases)
  Salmonellosis [ICD-11: 1A09]; [1]
• Formula: C21H38BrN
• IsoSMILES: CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1.[Br-]
• InChI: 1S/C21H38N.BrH/c1-4-5-6-7-8-9-10-11-12-16-19-22(2,3)20-21-17-14-13-15-18-21;/h13-15,17-18H,4-12,16,19-20H2,1-3H3;1H/q+1;/p-1
• InChIKey: KHSLHYAUZSPBIU-UHFFFAOYSA-M
• PubChem CID: 23705
• DrugBank ID: DB11105

Type(s) of Resistant Mechanism of This Drug

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-01: Infectious/parasitic diseases

Salmonellosis [ICD-11: 1A09]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Key Molecule: Efflux pump membrane transporter MdsA (MDSA) [1]

• Molecule Alteration: Expression; Up-regulation
• Resistant Disease: Salmonella enterica infection [ICD-11: 1A09.0]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Salmonella enterica serovar Typhimurium ATCC 14028s; 588858
• Experiment for Molecule Alteration: Quantitative real-time PCR
• Experiment for Drug Resistance: L agar plate method assay
• Mechanism Description: Overexpression or overproduction of MdsABC confers drug resistance.

Key Molecule: Efflux pump membrane transporter MdsB (MDSB) [1]

• Molecule Alteration: Expression; Up-regulation
• Resistant Disease: Salmonella enterica infection [ICD-11: 1A09.0]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Salmonella enterica serovar Typhimurium ATCC 14028s; 588858
• Experiment for Molecule Alteration: Quantitative real-time PCR
• Experiment for Drug Resistance: L agar plate method assay
• Mechanism Description: Overexpression or overproduction of MdsABC confers drug resistance.

Key Molecule: Efflux pump membrane transporter MdsC (MDSC) [1]

• Molecule Alteration: Expression; Up-regulation
• Resistant Disease: Salmonella enterica infection [ICD-11: 1A09.0]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Salmonella enterica serovar Typhimurium ATCC 14028s; 588858
• Experiment for Molecule Alteration: Quantitative real-time PCR
• Experiment for Drug Resistance: L agar plate method assay
• Mechanism Description: Overexpression or overproduction of MdsABC confers drug resistance.

References

• Ref 1: Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium. Mol Microbiol. 2006 Jan;59(1):126-41. doi: 10.1111/j.1365-2958.2005.04940.x.